Value of small dense low-density lipoprotein combined with residual lipoprotein particles in the diagnosis of atherosclerosis in patients with type 2 diabetes mellitus
Objective To explore the diagnostic value of serum small dense low-density lipoprotein(sd-LDL)combined with residual lipoprotein particles(RLPs)in patients with type 2 diabetes mellitus(T2DM)complicated with atherosclerosis(AS).Methods A total of 50 T2DM patients with AS admitted to Suzhou Municipal Hospital of Jiangsu Province from January 2020 to June 2022 were included in the study group,and 50 T2DM patients without AS were selected as the control group.The levels of blood lipids,blood glucose indexes,insulin resistance index,sd-LDL,RLPs,and lipoprotein-associated phospholipase A2(Lp-PLA2)were compared between the two groups.Logistic regression model was used to analyze the influencing factors of T2DM patients with AS,and receiver operating characteristic curve was used to analyze the diagnostic value of sd-LDL and RLPs for the disease.Results The levels of total cholesterol,triglyceride,low-density lipoprotein cholesterol,lipoprotein a,sd-LDL,RLPs,and Lp-PLA2 in the study group were higher than those in the control group,and the high density lipoprotein-cholesterol was lower than that in the control group,and the differences were statistically significant(P＜0.05).Multivariate analysis showed that sd-LDL(OR=1.264,95％CI:1.019-1.568),RLPs(OR=1.379,95％CI:1.064-1.786),Lp-PLA2(OR=1.842,95％CI:1.135-2.990),and lipoprotein a(OR=1.704,95％CI:1.058-2.744)were independent influencing factors for T2DM with AS(P＜0.05).Receiver operating characteristic curve analysis showed that sd-LDL and RLPs alone and in combination had certain diagnostic value for T2DM patients with AS(P＜0.05).Conclusion The serum levels of sd-LDL and RLPs are increased in T2DM patients with AS,which have predictive value for the occurrence of AS in T2DM patients.
Small dense low density lipoproteinResidual lipoprotein particlesAtherosclerosisType 2 diabetes mellitus
万方数据
维普
