Effect of lyophilized recombinant human brain natriuretic peptide assisted by bilevel positive airway pressure ventilator on patients with pneumocar-dial disease
Objective To investigate the effect of lyophilized recombinant human brain natriuretic peptide assisted by bilevel positive airway pressure(BPAP)ventilator on patients with pneumocardial disease.Methods A total of 236 patients with pneumocardial disease admitted to the 960th Hospital of the Chinese People's Liberation Army Joint Logistic Support Force from October 2020 to October 2022 were divided into control group(118 cases)and experimental group(118 cases)by random number table method.The control group was treated with lyophilized recombinant human brain natriuretic pep-tide,and the experimental group was treated with BPAP ventilator assisted lyophilized recombinant human brain natriuretic peptide.Both groups were treated for ten days.The clinical efficacy of the two groups was compared,the indexes of heart function,lung function,and blood gas before and after treatment were detected,and the adverse reactions of the two groups were recorded.Results The curative effect of the experimental group was better than that of the control group,and the dif-ference was statistically significant(P＜0.05).After treatment,stroke volume(SV)and left ventricular ejection fraction(LVEF)in two groups were higher than those before treatment,N-terminal brain natriuretic peptide precursor(NT-proBNP)was lower than that before treatment,and SV and LVEF in ex-perimental group were higher than those in the control group,and NT-proBNP was lower than that in the control group,the dif-ferences were statistically significant(P＜0.05).After treatment,the percentage of forced expiratory volume in one second to the expected value(FEV1％),FEV1/forced vital capacity(FVC),and partial pressure of oxygen in arterial blood(PaO2)in the two groups were higher than those before treatment,and the partial pressure of carbon dioxide in arterial blood(PaCO2)was lower than that before treatment,and the FEV1％,FEV1/FVC,and PaO2 in the experimental group were higher than those in the control group,PaCO2 was lower than that in the control group,the differences were statistically significant(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion BPAP ventilator assisted lyophilized recombinant human brain natriuretic peptide has a good effect on pneumocardial disease,and can improve the cardiopulmonary function and ar-terial blood gas index of patients.
Pneumocardial diseaseBilevel positive airway pressureLyophilized recombinant human brain natriuretic peptideCardiac function
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维普
