Effect of Shenmai Injection intervention on new organ damages in sepsis
Objective To observe the effect of Shenmai Injection intervention on the prognosis of sepsis and new organ damage.Methods A total of 181 adult sepsis patients admitted to the Intensive Care Unit(ICU)of Beijing Hospital of Traditional Chinese Medicine,Capital Medical University from January 2017 to October 2021 were selected as the subject Sepsis patients were divided into a newly diagnosed organ injury group(95 cases)and non-diagnosed organ injury group(86 cases)according to whether patients had new organ injury or not.The basic information of patients,relevant laboratory indicators,and intervention factors in the early stage,and relevant laboratory indicators after 7 d of treatment were collected.Multivariate logistic regression model was constructed to analyze the relevant pathogenesis factors,and the correlation between Shenmai Injection intervention and new organ injury was explored according to x2 test.Results The levels of shock within 72 h after admission,early fluid balance,sepsis-related organ failure assessment score admission to ICU and after treatment,and white blood cell count in the newly diagnosed organ injury group were higher than those in the non-diagnosed organ injury group,and the differences were highly statistically significant(P＜0.01).The proportion of Shenmai injection used in hospital,the levels of blood albumin and hemoglobin after treatment in the newly diagnosed orgain injury group were lower than those in the non-diagnosed organ injury group,and the differences were statistically significant(P＜0.05).Shenmai Injection intervention(OR=0.261,95％CI:0.109-0.626,P＜0.01)and hemoglobin after treatment(OR=0.978,95％CI:0.957-0.998,P＜0.05)were independent influencing factors of new organ injury.The patients with acute kidney injury and acute lung injury after Shenmai Injection intervention were less than those without Shenmai Injection(P＜0.01).There was no significant difference between Shenmai Injection and no Shenmai Injection in patients with new acute cardiac dysfunction(P＞0.05).Conclusion On the basis of routine treatment,intervention with Shenmai Injection can reduce the risk of new organ damages such as acute lung injury and acute kidney injury in sepsis patients.
Shenmai InjectionSepsisNew organ injuryAcute lung injuryAcute kidney injury
万方数据
维普
