Research progress on the protective mechanism of curcumin in low pressure and low oxygen environment
The low pressure and low oxygen environment threatens the health of the Han Chinese for urgent entering and long living in the plateau,preventing acute and chronic altitude sickness caused by low pressure and low oxygen is the focus of altitude medicine research.Curcumin is the main active ingredient extracted from the root stem of the traditional Chinese medicine Curcumae Longae Rhizoma,it has a wide range of pharmacological effects.Numerous cellular and animal studies have demonstrated the protective role of curcumin against tissue,organ,and cellular damage in low pressure and low oxygen environment.However,its protective effects and underlying mechanisms on various human body systems under low pressure and low oxygen environment remain unclear.This paper reviews the protective roles and potential mechanisms of curcumin on the respiratory,neurological,cardiovascular,and skeletal muscle systems under low pressure and low oxygen environment,offering valuable insights for further experimental or trial research in extreme regions,as well as future development in health foods and pharmaceuticals.