中国医药导报2024,Vol.21Issue(6) :58-61.DOI:10.20047/j.issn1673-7210.2024.06.13

山柰酚抗肝脏疾病的研究进展

Research progress of kaempferol against liver diseases

游云晖 周明艳 胡继成 祝哲 徐剑
中国医药导报2024,Vol.21Issue(6) :58-61.DOI:10.20047/j.issn1673-7210.2024.06.13

山柰酚抗肝脏疾病的研究进展

Research progress of kaempferol against liver diseases

游云晖 1周明艳 2胡继成 1祝哲 1徐剑1
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作者信息

  • 1. 海南医学院第二附属医院肝胆胰外科,海南海口 570100
  • 2. 海南医学院第二附属医院临床医学研究所,海南海口 570100
  • 折叠

摘要

肝脏疾病种类繁多,临床症状反复难愈,尽管对肝脏疾病治疗手段很多,但其临床效果仍然欠佳.因此,临床上有必要寻找治疗肝脏疾病的新药以提高患者生存率.山柰酚作为中药活性单体,在调节肝脏疾病方面具有独特的优势,有望改善肝脏疾病的临床预后.本文通过回顾近年来有关山柰酚治疗肝纤维化、非酒精性脂肪肝病、急性肝衰竭、肝癌的文献与研究,对山柰酚抗肝脏疾病的效应及分子机制进行整理与归纳,以期为山柰酚作为护肝药物应用于临床提供理论依据.

Abstract

There are many kinds of liver diseases,and the clinical symptoms are repeatedly difficult to cure.Although there are many treatment methods for liver diseases,the clinical effect is still poor.Therefore,it is clinically necessary to find new drugs to treat liver diseases to improve the survival rate of patients.Kaempferol,as an active monomer of traditional Chinese medicine,has a unique advantage in the treatment of liver diseases and is expected to improve the clinical prognosis of liver diseases.By reviewing the literatures and studies on kaempferol in the treatment of liver fibrosis,non-alcoholic fatty liver disease,acute liver failure,and liver cancer in recent years,the effects and molecular mechanisms of kaempferol against liver diseases were summarized,in order to provide theoretical basis for the clinical application of kaempferol as liver protective drugs.

关键词

山柰酚/肝纤维化/非酒精性脂肪肝病/急性肝衰竭/肝癌

Key words

Kaempferol/Hepatic fibrosis/Non-alcoholic fatty liver disease/Acute liver failure/Liver cancer

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基金项目

海南省重大科技计划项目(ZDKJ2019009)

出版年

2024
中国医药导报
中国医学科学院

中国医药导报

CSTPCD
影响因子:1.759
ISSN:1673-7210
参考文献量28
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