Effects of Donepezil Hydrochloride combined with Sun's repeated tran-scranial acupuncture in the treatment of Alzheimer's disease
Objective To observe the clinical efficacy of Donepezil Hydrochloride combined with Sun's repeated transcranial acupuncture in the treatment of Alzheimer's disease(AD).Methods From September 2022 to September 2023,90 AD patients who were admitted to the Acupuncture and Moxibustion Clinic,the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine Hanan Branch Hospital were divided into observation group,control group A,and control group B by random number table method,with 30 cases in each group.Control group A was treated with oral administration of Donepezil Hydrochloride,control group B was treated with Sun's repeated transcranial acupuncture,and observation group was treated with Donepezil Hydrochloride combined with Sun's repeated transcranial acupuncture,treated for eight weeks.Tts clinical effect was evaluated.The scores of the mini mental state examination(MMSE),Alzheimer's disease assessment scale cognitive subscale(ADAS-cog),and activities of daily living(ADL),as well as serum homocysteine(Hey)levels before treatment and after four and eight weeks of treatment among three groups were compared.Results The clinical efficacy of the observation group was better than that of control group A and control group B,and the differences were statistically significant(P＜0.05).At 4 and 8 weeks after treatment,MMSE scores in three group were higher than before treatment,ADAS-cog,ADL scores and serum Hcy levels were lower than before treatment,the differences were statistically significant(P＜0.05).The MMSE scores at 8 weeks after treatment were higher than those at 4 weeks after treatment,and the scores of ADAS-cog,ADL and serum Hey levels were lower than those at 4 weeks after treatment,with statistical significances(P＜0.05).At 8 weeks after treatment,MMSE scores in observation group were higher than those in control group A and control group B,ADAS-cog,ADL scores and serum Hey levels were lower than those in control group A and control group B,and the differences were statistically significant(P＜0.05).Conclusion Donepezil Hydrochloride combined with Sun's repeated transcranial acupuncture can improve the cognitive function and behavioral ability of patients with mild to moderate AD,and reduce the level of serum Hcy,and the effect is better than oral Donepezil and Sun's repeated transcranial acupuncture,which is worthy of clinical promotion.
Sun's repeated transcranial acupunctureAlzheimer's diseaseDonepezil HydrochlorideCognitive function
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