Research progress on the relationship between ferroptosis and diabetic nephropathy
Diabetic nephropathy is one of the most important diabetic microvascular complications,which has become an important cause of chronic kidney disease and end-stage kidney disease.A large number of studies have shown that iron death is closely related to the onset of diabetic nephropathy.Ferroptosis is a new type of iron-dependent programmed cell death,which is characterized by formation of iron-dependent reactive oxygen species,and imbalance in redox status resulting in the lipid peroxidation of polyunsaturated fatty acid in cell membranes.During the occurrence and development of diabetic nephropathy,ferroptosis can not only damage renal tubules,but also is closely related to the injury of mesangial cells and podocyte.In this paper,the recent research progress on the signaling regulation mechanism of ferroptosis,as well as the role and molecular mechanism of ferroptosis in the pathogenesis of diabetic nephropathy is reviewed in order to explore new therapeutic targets and strategies for clinical diagnosis and treatment of diabetic nephropathy.
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