Research progress on the role of nuclear factor-erythroid 2-related factor 2 in hepatic ischemia-reperfusion injury and the intervention of anesthetic drugs
Hepatic ischemia-reperfusion injury(IRI)is a common type of liver injury that severely affects patient prognosis.Nuclear factor-erythroid 2-related factor 2(Nrf2)is an important transcription factor involved in a variety of cellular physiological activities.Studies have shown that Nrf2 plays a significant regulatory role in hepatic IRI,and activation of Nrf2 and related pathways can scavenge reactive oxygen species,reduce oxidative stress injury,and thus alleviate hepatic IRI.In recent years,the modulation of Nrf2 signaling pathway by anesthesia drugs has achieved some results in alleviating hepatic IRI in basic experiments and clinical trials,but it is still in experimental stage.This paper reviews the role and mechanism of Nrf2 in hepatic IRI by analyzing the research progress related to anesthetic drugs in recent years,with the aim of providing a new direction for the prevention and treatment of hepatic IRI.
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