首页|基于免疫调节探讨中医药对肛瘘术后促愈机制的研究进展

基于免疫调节探讨中医药对肛瘘术后促愈机制的研究进展

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肛瘘是以肛周硬结、反复破溃流脓、瘙痒为主要临床表现的感染性疾病.手术是其主要治疗方法.中医药治疗肛瘘术后创面愈合临床效果显著,可有效调节机体免疫功能、控制创面感染、减轻术后并发症、促进肉芽组织生长,从而达到消肿祛瘀、敛疮生肌之效.但中医药治疗肛瘘术后创面愈合尚存在研究方法单一、作用机制研究不足等问题.本文通过阐述相关炎症因子、生长因子、信号通路、免疫球蛋白和基质金属蛋白酶等影响肛瘘术后创面愈合的机制,旨在为基础研究和临床实践提供可靠的理论依据和新的思路.
Research progress of exploring the healing mechanism of traditional Chi-nese medicine on postoperative anal fistula based on immune regulation
Anal fistula is an infectious disease with perianal hardness,recurrent rupture and pus flow,itching as the main clinical manifestations.Surgery is the main treatment method.Traditional Chinese medicine treatment of postoperative wound healing of anal fistula is clinically effective,can effectively control wound infection,regulate the body's immune function,reduce postoperative complications,promote the growth of granulation tissue,so as to achieve the effect of eliminating swelling and eliminating blood stasis,convergence of sores and muscle growth.However,Chinese medicine treatment of postoperative wound healing of anal fistula still exists in a single research method,insufficient research on the mechanism of action and other problems.In this paper,we describe the mechanisms of inflammatory factors,growth factors,signaling pathways,immunoglobulins and matrix metalloproteinases affecting postoperative wound healing after anal fistula surgery,aiming to provide a reliable theoretical basis and new ideas for basic research and clinical practice.

Traditional Chinese medicineAnal fistulasImmune regulationWound healingMechanismOverview

李昌盛、畅立强、李仲云、宋杰、张高竭

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山西中医药大学第一临床学院,山西太原 030024

山西省中医院肛肠科,山西太原 030012

中医药 肛瘘 免疫调节 创面愈合 机制 综述

山西省卫生健康委科研项目山西省中医药局科研项目

20220912020ZYYZ018

2024

中国医药导报
中国医学科学院

中国医药导报

CSTPCD
影响因子:1.759
ISSN:1673-7210
年,卷(期):2024.21(7)
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