Expression of β endorphin,cyclooxygenase-2,and dopamine receptor D 2 in serum of patients with right to left shunt and migraine with aura,and their association with anxiety
Objective To study the expression of β-endorphin(β-EP),cyclooxygenase-2(COX-2),and dopamine receptor D2(DRD2)in serum of patients with right to left shunt(RLS)and migraine with aura,and their relationship with anxiety.Methods A total of 214 patients with migraine with aura who were found to have RLS in Jilin Province FAW General Hospital from July 2022 to July 2023 were selected and recorded as the RLS migraine group,and 50 patients with migraine with aura without RLS were selected as the control group.Serum levels of β-EP,COX-2,DRD2,and self-rating anxiety scale(SAS)score were compared between the two groups.According to the examination results,the patients of RLS migraine group were divided into few,medium,and large RLS migraine group,with 90,46,and 78 cases,respectively.The serum β-EP,COX-2,DRD2 levels,and SAS scores of the three groups were compared.Spearman correlation coefficient was used to analyze the relationship between serum β-EP,COX-2,DRD2 levels,RLS grade,and SAS score in RLS migraine group.Results Serum β-EP and DRD2 levels in RLS migraine group were lower than those in control group,and COX-2 level and SAS score were higher than those in control group,the differences were statistically significant(P＜0.05).Serum levels ofβ-EP and DRD2 in medium and large RLS migraine group were lower than those in few RLS migraine group,and those in large RLS migraine group were lower than those in medium RLS migraine group,the differences were statistically significant(P＜0.05).Serum COX-2 level and SAS score in medium and large RLS migraine group were higher than those in few RLS migraine group,and those in large RLS migraine group were higher than those in medium RLS migraine group,the differences were statistically significant(P＜0.05).Correlation analysis results showed that serum β-EP and DRD2 levels were negatively correlated with RLS grade and SAS score(rs＜0,P＜0.05),and serum COX-2 level was positively correlated with RLS grade and SAS score(rs＞0,P＜0.05).Conclusion With the increase of RLS grade in patients with RLS and migraine with aura,the expression of β-EP and DRD2in serum decreased,and the expression of COX-2 increased,and the three are closely related to the anxiety state of patients.
Migraine with auraRight to left shuntβ-endorphinsCyclooxygenase-2Dopamine receptor D 2Anxiety
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