Effects of Xianlong Decoction on serum airway remodeling molecular level and small airway function in patients with chronic obstructive pulmonary disease with deficiency of both lung and kidney combined with blood stasis syndrome
Objective To investigate the effects of Xianlong Decoction on serum airway remodeling molecular level and small airway function in patients with chronic obstructive pulmonary disease(COPD)with deficiency of both lung and kidney combined with blood stasis syndrome.Methods A total of 86 patients with deficiency of both lung and kidney combined with blood stasis syndrome of stable COPD were selected from the Department of Pneumology,Hangzhou Lin'an Traditional Chinese Medicine Hospital,Zhejiang Province from July 2021 to August 2022,and they were divided into observation group and control group by random number table method,with 43 cases in each group.Both groups were given routine treatment for COPD,and the observation group was given Xianlong Decoction on the basis of routine treatment,the course of treatment was 12 weeks.Lung function,traditional Chinese medicine syndrome score,airway remodeling molecular level,Wnt5a/extracellular signal-regulated kinase signaling pathway factor leve l and CT small airway function before and after treatment were compared between the two groups.Results After treatment,forced expiratory volume in one second(FEV1),FEV1/forced vital capacity,forced expiratory flow at 50%of forced vital capacity exhaled,forced expiratory flow during middle half of forced vital capacity,and forced expiratory flow at 75%of forced vital capacity exhaled were all higher than before treatment,and those in observation group were higher than those in control group(P＜0.05).The scores of traditional Chinese medicine symptoms in both groups were lower than before treatment,and those in observation group were lower than those in control group(P＜0.05).After treatment,the transforming growth factor-β1,nicotinamide adenine dinucleotide phosphate oxidase 4,nuclear factor-κB,and matrix metalloproteinase 9 in two groups were lower than before treatment,and those in observation group were lower than those in control group(P＜0.05).After treatment,Wnt5a,phosphorylated extracellular signaling regulated kinase 1/2,and total extracellular regulatory protein kinase 1/2 in both groups were lower than before treatment,and those in observation group were lower than those in control group(P＜0.05).After treatment,the lumen diameter of the left upper tip segment,the right upper tip segment,the base segment of the left lower lobe and the base segment of the right lower lobe in both groups was higher than before treatment,and the lumen diameter of the right upper tip segment in observation group was higher than that in control group(P＜0.05).After treatment,the tube wall thickness of the right upper lobe tip segment and the left lower lobe base segment in both groups was lower than before treatment,and that in observation group was lower than that in control group(P＜0.05).After treatment,the lumen area of the left upper tip segment,the right upper tip segment,and the base segment of the left lower lobe in both groups was larger than before treatment,and the lumen area of the right lower lobe base segment in both groups was smaller than before treatment,and the lumen area of the left upper tip segment and the right upper tip segment in observation group was larger than that in the control group(P＜0.05).After treatment,the tube wall area of the left upper tip segment,the right upper tip segment,and the left lower base segment in both groups was smaller than before treatment,and the tube wall area of the right upper tip segment and the left lower base segment in observation group was smaller than that in control group(P＜0.05).Conclusion Xianlong Decoction can effectively improve lung function and small airway function in stable COPD patients with deficiency of both lung and kidney combined with blood stasis syndrome.The mechanism may be related to inhibiting the expression of Wnt5a/extracellular signaling regulated kinase signaling pathway,down-regulating the level of airway remodeling molecules,and inhibiting airway remodeling.
Xianlong DecoctionChronic obstructive pulmonary diseaseDeficiency of both lung and kidney combined with blood stasis syndromeWnt5a/extracellular signaling regulated kinase signaling pathwayLung functionSmall airway function
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