首页|补肾祛瘀汤治疗老年肾虚血瘀证骨质疏松症患者的效果

补肾祛瘀汤治疗老年肾虚血瘀证骨质疏松症患者的效果

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目的 探讨补肾祛瘀汤治疗老年骨质疏松症(OP)患者的临床效果.方法 选取2018年 1月至 2022年 12月江苏省苏州市中西医结合医院收治的老年OP患者 160例,采用随机数字表法将其分为补肾祛瘀组和西药组,各80例.西药组给予碳酸钙D3 片+阿法骨化醇片治疗,补肾祛瘀组在西药组基础上加用补肾祛瘀汤.比较两组临床疗效;比较两组治疗前后中医证候积分、骨密度(腰椎、股骨颈)、骨代谢指标[骨特异性碱性磷酸酶(BALP)、Ⅰ型原胶原N-端前肽(PINP)、抗酒石酸酸性磷酸酶(TRACP-5b)、Ⅰ型原胶原C-端前肽(CTX)]水平;比较两组不良反应发生率.结果 两组各有 2 例患者中途退出研究.补肾祛瘀组临床疗效优于西药组,差异有统计学意义(P<0.05).治疗后,两组中医证候积分均低于治疗前,且补肾祛瘀组低于西药组,差异有统计学意义(P<0.05).治疗后,两组腰椎和股骨颈骨密度均高于治疗前,且补肾祛瘀组高于西药组,差异有统计学意义(P<0.05).治疗后,两组PINP、CTX及补肾祛瘀组BALP、TRACP-5b均低于治疗前,差异有统计学意义(P<0.05).补肾祛瘀组BALP、TRACP-5b、PINP、CTX低于西药组,差异有统计学意义(P<0.05).两组不良反应总发生率比较,差异无统计学意义(P>0.05).结论 补肾祛瘀汤联合西药用于治疗老年OP可有效改善患者临床症状,调节骨代谢转换平衡,增加骨密度.
Effect of Bushen Quyu Tang on elderly patients with osteoporosis of kid-ney deficiency and blood stasis syndrome
Objective To investigate the clinical effect of Bushen Quyu Tang in the treatment of elderly patients with osteoporosis(OP).Methods A total of 160 cases of elderly OP patients admitted to Suzhou Hospital of Integrated Traditional Chinese and Western Medicine from January 2018 to December 2022 were selected and they were divided into invigorating the kidney and dispelling stasis group and western medicine group by random number table method,with 80 cases in each group.The western medicine group was given Calcium Carbonate D 3 Tablets + Alfacalcitol Tablets for treatment,and the invigorating the kidney and dispelling stasis group was given Bushen Quyu Tang on the basis of the western medicine group.The clinical effect of the two groups was compared.The traditional Chinese medicine syndrome score,bone mineral density(lumbar spine,femoral neck),and bone metabolism indexes(bone specific alkaline phosphatase[BALP],cross-linked N-terminal propeptide of type Ⅰ collagen[PINP],tartrate-resistant acid phosphatase[TRACP-5b]and C-terminal pro-peptide of type Ⅰ collagen[CTX])were compared between the two groups before and after treatment.The incidence of adverse reactions was compared between the two groups.Results A total of 2 patients in each of the two groups withdrew from the study halfway.The clinical effect of invigorating the kidney and dispelling stasis group was better than that of western medicine group,and the differences were statistically significant(P<0.05).After treatment,the traditional Chinese medicine syndrome scores of the two groups were lower than before treatment,and the invigorating kidney and dispelling stasis group was lower than the western medicine group,the differences were statistically significant(P<0.05).After treatment,bone mineral bone of lumbar spine and femoral neck in both groups were higher than before treatment,and the invigorating the and dispelling stasis group was higher than the western medicine group,the differences were statistically significant(P<0.05).After treatment,the BALP,TRACP-5b,PINP,CTX and BALP and TRACP-5b in the invigorating the kidney and dispelling stasis group were lower than before treatment,the differences were statistically significant(P<0.05);BALP,TRACP-5B,PINP and CTX in the invigorating the kidney and dispelling stasis group were lower than those in the western medicine group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Bushen Quyu Tang combined with western medicines used in the treatment of elderly OP can effectively improve the clinical symptoms of patients,regulate the balance of bone metabolism conversion,and increase bone density.

Bushen Quyu TangElderly patientsOsteoporosisBone densityBone metabolismCalcium carbonate D 3Alfacalcitol Tablets

李俊、周文彬、蔡丹宇、陈建生

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江苏省苏州市中西医结合医院骨伤二科,江苏苏州 215101

补肾祛瘀汤 老年 骨质疏松症 骨密度 骨代谢 碳酸钙D3 阿法骨化醇片

江苏省研究生科研与实践创新计划

SJCX20-0616

2024

中国医药导报
中国医学科学院

中国医药导报

CSTPCD
影响因子:1.759
ISSN:1673-7210
年,卷(期):2024.21(7)
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