Effect of Bushen Quyu Tang on elderly patients with osteoporosis of kid-ney deficiency and blood stasis syndrome
Objective To investigate the clinical effect of Bushen Quyu Tang in the treatment of elderly patients with osteoporosis(OP).Methods A total of 160 cases of elderly OP patients admitted to Suzhou Hospital of Integrated Traditional Chinese and Western Medicine from January 2018 to December 2022 were selected and they were divided into invigorating the kidney and dispelling stasis group and western medicine group by random number table method,with 80 cases in each group.The western medicine group was given Calcium Carbonate D 3 Tablets + Alfacalcitol Tablets for treatment,and the invigorating the kidney and dispelling stasis group was given Bushen Quyu Tang on the basis of the western medicine group.The clinical effect of the two groups was compared.The traditional Chinese medicine syndrome score,bone mineral density(lumbar spine,femoral neck),and bone metabolism indexes(bone specific alkaline phosphatase[BALP],cross-linked N-terminal propeptide of type Ⅰ collagen[PINP],tartrate-resistant acid phosphatase[TRACP-5b]and C-terminal pro-peptide of type Ⅰ collagen[CTX])were compared between the two groups before and after treatment.The incidence of adverse reactions was compared between the two groups.Results A total of 2 patients in each of the two groups withdrew from the study halfway.The clinical effect of invigorating the kidney and dispelling stasis group was better than that of western medicine group,and the differences were statistically significant(P<0.05).After treatment,the traditional Chinese medicine syndrome scores of the two groups were lower than before treatment,and the invigorating kidney and dispelling stasis group was lower than the western medicine group,the differences were statistically significant(P<0.05).After treatment,bone mineral bone of lumbar spine and femoral neck in both groups were higher than before treatment,and the invigorating the and dispelling stasis group was higher than the western medicine group,the differences were statistically significant(P<0.05).After treatment,the BALP,TRACP-5b,PINP,CTX and BALP and TRACP-5b in the invigorating the kidney and dispelling stasis group were lower than before treatment,the differences were statistically significant(P<0.05);BALP,TRACP-5B,PINP and CTX in the invigorating the kidney and dispelling stasis group were lower than those in the western medicine group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Bushen Quyu Tang combined with western medicines used in the treatment of elderly OP can effectively improve the clinical symptoms of patients,regulate the balance of bone metabolism conversion,and increase bone density.
Bushen Quyu TangElderly patientsOsteoporosisBone densityBone metabolismCalcium carbonate D 3Alfacalcitol Tablets