Association between ultra-early amyloid beta deposition and default network patterns in people at risk for Alzheimer's disease
Objective To investigate the relationship between ultra-early cerebrospinal fluid amyloid beta(Aβ)deposition and functional connectivity of the default network(DMN)in people at risk of Alzheimer's disease.Methods Participants with mild cognitive impairment enrolled in the Alzheimer's Disease Neuroimaging Program in North America from July 2010 to December 2018 were divided into Aβ declining group(25 cases)and Aβ stable group(19 cases)based on changes in cerebrospinal fluid Aβ during 36 months of follow-up.Functional brain MRI was used to study the relationship between cerebrospinal fluid Aβ decline,DMN functional connectivity and cognitive function.Results Compared with Aβ stable group,the time of trail making test-B(MTT-B)in Aβ declining group was longer during follow-up(P＜0.05).In bilateral middle occipital gyrus and left middle temporal gyrus,DMN functional connectivity in A β declining group was significantly lower than that in Aβ stable group(P＜0.01).The functional connectivity of the left medial temporal gyrus was negatively correlated with MTT-B time(r＜0,P＜0.05).Conclusion Ultra-early Aβ deposition is closely related to the decrease of temporal occipital DMN functional connectivity,and leads to the impairment of executive function.
Amyloid-β depositionDefault mode networkFunctional connectivityExecutive function
NETL
NSTL
万方数据
