Expression of transcriptional co-activator in lung cancer tissues and its relationship with prognosis of patients
Objective To explore the expression of transcriptional co-activator(TAZ)in tissues of non-small cell lung cancer(NSCLC)and relationship with prognosis of TAZ NSCLC patients.Methods A total of 118 NSCLC patients admitted to the Second People's Hospital of Liaocheng from January to December 2019 were selected,and their clinical case data were collected.Immunohistochemical method were used to observe the expression of TAZ in cancer tissues and paired adjacent tissues.Kaplan-Meier survival curve and Cox regression were used to analyze the relationship between TAZ expression and prognosis of lung cancer patients.Results Among the 118 patients with lung cancer,there were 70 cases of positive expression of TAZ in cancer tissues,and 41 cases of positive expression in paracancer tissues.The positive expression rate of TAZ in cancer tissue was higher than that in paracancer tissues(P<0.05).The Kaplan-Meier survival curve results showed that the overall survival rate of TAZ positive expression patients was lower than that of TAZ negative expression patients(P<0.05).Cox regression analysis showed that positive TAZ expression,tumor diameter≥3 cm,lymph node metastasis,and TNM stage Ⅲ were independent risk factors affecting patient prognosis.Conclusion High expression of TAZ in lung cancer tissues is closely related to tumor diameter,TNM staging,and lymph node metastasis,which is an independent influencing factor on the prognosis of lung cancer.The positive expression of TAZ may be a new biological marker affecting the prognosis of NSCLC patients.
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