Molecular feature and clinical research progress of undifferentiated/dedif-ferentiated endometrial carcinoma
Undifferentiated/dedifferentiated endometrial carcinoma is rare and highly aggressive tumor with poor prognosis.It is often diagnosed at an advanced stage and resistant to conventional chemotherapy.Therefore,new treatment strategies need to be explored urgently.Undifferentiated/dedifferentiated endometrial carcinoma has genetic characteristics that are different from other common endometrial carcinomas.Its tumorigenic pathways have unique features,such as gene inactivation of microsatellite instability/mismatch repair proteins,and switch in mat ing type/sucrose non fermentation chromatin remodeling complexes.Therefore,molecular detection is of great significance for the clinical management of undifferentiated/dedifferentiated endometrial carcinoma,and participation in clinical trials and targeted therapy.In this review,the molecular features and clinical studies on those two uncommon subtypes are summarized in order to identify potential molecular targets for current and future research.
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