Risk factors of Helicobacter pylori infection and its correlation with serum PGⅠ,PGⅡ,and G-17
Objective To investigate the risk factors of Helicobacter pylori(Hp)infection and its correlation with serum pepsinogenⅠ(PG-Ⅰ),pepsinogenⅡ(PG-Ⅱ)and gastrin-17(G-17).Methods A total of 816 patients who underwent Hp screening in the physical examination center of the Fifth People's Hospital of Datong City,Shanxi Province from January 2020 to January 2022 were selected as the study objects.They were divided into observation group(310 Hp infection cases)and control group(506 Hp uninfected cases)according to HP infection.Hp infection and its influencing factors were analyzed,serum PGⅠ,PGⅡ,and G-17 levels were compared the two groups,and the correlation between Hp infected persons and serum PGⅠ,PGⅡ,and G-17 was analyzed.Results Among the 816 subjects,426 were males and 390 were females.The positive infection rate of male was higher than that of female,and the difference was statistically significant(P＜0.05).There were no significant differences in Hp infection rate among different age and education level(P＞0.05).There were significant differences in the positive rate of Hp infection among different groups who drank alcohol,often drank raw water,often ate out,often ate spicy food,diagnosis and treatment history of stomach disease,and family history of Hp infection(P＜0.05).Multivariate logistic analysis showed that drinking alcohol,often drinking raw water,often eating out,often eating spicy food,diagnosis and treatment history of stomach disease,and family history of Hp infection were the risk factors for Hp infection in the physical examination subjects(P＜0.05).The levels of serum PGⅠ,PGⅡ,and G17 in observation group were higher than those in control group,and the differences were statistically significant(P＜0.05).Hp infection was positively correlated with serum PGⅠ,PⅡ,and G-17 levels(r＞0,P＜0.05).Conclusion Hp infection in physical examination population is related to many factors,especially abnormal serum PGⅠ,PGⅡ,and G-17 levels are related to Hp infection,which has high clinical value.
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