Value of oral administration of Rivaroxaban,Dabigatran,and warfarin in the prevention of stroke after radiofrequency ablation of atrial fibrillation
Objective To investigate the value of Rivaroxaban,Dabigatran,and warfarin in the prevention of stroke after radiofrequency ablation of atrial fibrillation.Methods A total of 120 patients with atrial fibrillation treated in Fuyang People's Hospital of Anhui Province from January 2020 to October 2022 were selected and randomly divided into three groups by random number table method,with 40 cases in each group.Rivaroxaban group(oral Rivaroxaban,15 mg once daily),Dabigatran group(oral Dabigatran,110 mg twice daily)and warfarin group(oral warfarin,the initial dose was 2.5 mg/time,once a day,and the dose of warfarin could be increased or decreased by 0.625 mg per time according to the target international normalized ratio[INR]of 2.0-3.0).All three groups were treated for three months.After three months of treatment,coagulant function,and levels of hypersensitive C-reactive protein(hs-CRP)and homocysteine(Hcy),and the incidence of adverse reactions were compared among the three groups;followed up for six months,the incidence of thrombosis and bleeding evnts were compared among the three groups.Results After treatment,INR,prothrombin time(PT),and activated partial thromboplastin time(APTT)in three groups were higher than before treatment,and INR,PT,and APTT in Rivaroxaban group and Dabigatran group were lower than those in warfarin group(P＜0.05).After treatment,the levels of hs-CRP and Hcy were decreased compared with before treatment,and levels of hs-CRP and Hcy in the Rivaroxaban group and Dabigatran group were lower than those in the warfarin group(P＜0.05).There were no statistically significant differences in the incidence of thrombosis and total incidence of adverse reactions among the three groups(P＞0.05).The incidence of minor bleeding in the Dabigatran group was lower than that in the warfarin group(P＜0.05).Conclusion Rivaroxaban,Dabigatran,and warfarin can effectively prevent stroke after atrial fibrillation radiofrequency ablation,but Rivaroxaban and Dabigatran are more beneficial to reduce bleeding risk,improve coagulation function,regulate hs-CRP and Hcy levels,and have higher clinical application value.
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