Analysis of factors influencing the therapeutic effect of platelet transfusion in patients with acute myeloid leukemia
Objective To explore the influencing factors of platelet transfusion efficacy in patients with acute myeloid leukemia(AML).Methods A total of 120 patients with AML who received platelet transfusion treatment in Yantai Affiliated Hospital of Binzhou Medical University from December 2021 to December 2022 were selected as the research objects,including 52 cases of ineffective transfusion group and 68 cases of effective transfusion group.The general data of the two groups were analyzed by statistical software SPSS 23.0,and the risk factors were analyzed.Results The results of univariate analysis showed that there were statistically significant differences in platelet transfusion efficacy among AML patients with different ages,spleen,active bleeding,platelet antibodies,co-infection,infusion times and fever before and after infusion(P＜0.05).The results of multivariate analysis showed that age(18-＜60 years old group[OR=6.324,95%CI:1.1953-20.473],≥60 years old group[OR=0.121,95%CI:0.019-0.757]),spleen(OR=2.850,95%CI:1.063-7.638),co-infection(OR=9.994,95%CI:3.109-32.130)and the number of blood transfusions(OR=5.053,95%CI:1.502-17.000)were the related factors affecting the platelet transfusion efficacy in patients with AML(P＜0.05).Conclusion Age,spleen,co-infection and the number of blood transfusions are risk factors that affect the efficacy of platelet transfusion in AML patients.Targeted preventive measures can be taken for patients with related clinical characteristics to provide better platelet transfusion efficacy for AML patients.
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