A case report of acute cerebral infarction combined with adverse reactions of concomitant rhabdomyolysis,myocarditis,and dermatitis medicamentosa
Statins are commonly used in the treatment of acute cerebral infarction.The adverse reactions of statins are common,such as abnormal liver function and gastrointestinal reaction,but rhabdomyolysis and myocarditis are very rare,which can lead to acute renal failure,electrolyte disturbance,arrhythmia,acute heart failure and other serious consequences.In order to increase the attention of clinicians to the adverse drug reactions caused by statins,a 67-year-old female patient was admitted to Nanchong Central Hospital,Sichuan Province with left limb weakness and numbness,diagnosed as acute pontine infarction,and was treated according to conventional cerebral infarction.During the period,the patient developed red skin rash,dyspnea,muscle pain of lower limbs,and weakness of limbs,accompanied by obvious abnormality of hypersensitive troponin T,myoglobin,creatine kinase-MB subtype,B-type natriuretic peptide precursor,and electrocardiogram.Statin drugs were discontinued,glucocorticoid therapy was given,and cardiac function was improved,and the above indexes all decreased significantly.Finally,the patient was discharged from hospital with improvement.The case was diagnosed as rhabdomyolysis and myocarditis caused by statins by association evaluation method of National Adverse Drug Reaction Monitoring Center.Statin therapy should be individualized and serious adverse drug reactions can be avoided by screening for the risk of statin associated myopathy and by avoiding drug combinations that increase the risk of myopathy.
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