Relationship between connective tissue growth factor and plasminogen levels in dialyzate and peritoneal solute transport rate in peritoneal dialysis patients
Objective To investigate the correlation of the levels of connective tissue growth factor(CTGF)and plasminogen activator inhibitor-1(PAI-1)in dialyzate and peritoneal solute transport rate(PSTR)in patients with peritoneal dialysis(PD).Methods One hundred and fifty-two PD patients admitted to the Second People's Hospital of Lianyungang in Jiangsu Province from January 2020 to December 2022 were selected and categorized into rapid transit group and non-rapid transit group according to the standard peritoneal balance test.The levels of CTGF and PAI-1 in dialyzate were measured by enzyme-linked immunosorbent assay.Multi-factor logistic regression was used to analyze the factors influencing the rapid transfer of PSTR in PD patients,and the value of the levels of CTGF and PAI-1 in dialyzate for assessing the rapid transfer of PSTR in PD patients was analyzed using receiver operating characteristic curves.Results The incidence of PSTR rapid transit in 152 PD patients was 57.24%(87/152).The levels of CTGF and PAI-1 in dialyzate were higher in the rapid transit group than those in the non-rapid transit group(P＜0.05).The dialysis age and nighttime ultrafiltration volume of the rapid transit group were higher than those of the non-rapid transit group,while the level of albumin was lower than that of the non-rapid transit group(P＜0.05).The prolonged dialysis age(OR=1.051,95%CI:1.023-1.081)and elevated CTGF(OR= 1.298,95%CI:1.165-1.446),PAI-1(OR=1.408,95%CI:1.205-1.646)were the independent risk factors of rapid transport of PSTR in patients with PD(P＜0.05).The area under the curve of CTGF combined with PAI-1 in dialyzate to predict the rapid transport of PSTR in PD patients was higher than that of either alone(P＜0.05).Conclusion Elevated levels of CTGF and PAI-1 in dialyzate are independently associated with rapid transport of PSTR in PD patients,and CTGF combined with PAI-1 is of higher value in the assessment of rapid transport of PSTR in PD patients,and may become an auxiliary assessment index of PSTR rapid transport in PD patients.
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