透析液中结缔组织生长因子、纤溶酶水平与腹膜透析患者腹膜溶质转运速率的关系
Relationship between connective tissue growth factor and plasminogen levels in dialyzate and peritoneal solute transport rate in peritoneal dialysis patients
钱娜 1李慧 1何传梅 1刘晓东1
作者信息
- 1. 江苏省连云港市第二人民医院肾内科,江苏连云港 222000
- 折叠
摘要
目的 探讨透析液中结缔组织生长因子(CTGF)、纤溶酶原激活物抑制剂-1(PAI-1)水平与腹膜透析(PD)患者腹膜溶质转运速率(PSTR)的关系.方法 选取 2020 年 1 月至 2022 年 12 月江苏省连云港市第二人民医院收治的152例PD患者,根据标准腹膜平衡试验分为快速转运组和非快速转运组.采用酶联免疫吸附试验检测透析液中CTGF、PAI-1水平.采用多因素logistic回归分析PD患者PSTR快速转运的影响因素,采用受试者操作特征曲线分析透析液中CTGF、PAI-1 水平对PD患者PSTR快速转运的评估价值.结果 152 例PD患者PSTR快速转运发生率为57.24%(87/152).快速转运组透析液中CTGF、PAI-1水平高于非快速转运组(P＜0.05).快速转运组透析龄、夜间超滤量高于非快速转运组,白蛋白水平低于非快速转运组(P＜0.05).透析龄延长(OR= 1.051,95%CI:1.023～1.081)和CTGF(OR=1.298,95%CI:1.165～1.446)、PAI-1(OR=1.408,95%CI:1.205～1.646)升高为PD患者PSTR快速转运的独立危险因素(P＜0.05).透析液中CTGF联合PAI-1预测PD患者PSTR快速转运的曲线下面积大于二者单独预测(P＜0.05).结论 透析液中CTGF、PAI-1水平升高与PD患者PSTR快速转运独立相关,二者联合对PD患者PSTR快速转运评估价值较高,可能成为PD患者PSTR快速转运的辅助评估指标.
Abstract
Objective To investigate the correlation of the levels of connective tissue growth factor(CTGF)and plasminogen activator inhibitor-1(PAI-1)in dialyzate and peritoneal solute transport rate(PSTR)in patients with peritoneal dialysis(PD).Methods One hundred and fifty-two PD patients admitted to the Second People's Hospital of Lianyungang in Jiangsu Province from January 2020 to December 2022 were selected and categorized into rapid transit group and non-rapid transit group according to the standard peritoneal balance test.The levels of CTGF and PAI-1 in dialyzate were measured by enzyme-linked immunosorbent assay.Multi-factor logistic regression was used to analyze the factors influencing the rapid transfer of PSTR in PD patients,and the value of the levels of CTGF and PAI-1 in dialyzate for assessing the rapid transfer of PSTR in PD patients was analyzed using receiver operating characteristic curves.Results The incidence of PSTR rapid transit in 152 PD patients was 57.24%(87/152).The levels of CTGF and PAI-1 in dialyzate were higher in the rapid transit group than those in the non-rapid transit group(P＜0.05).The dialysis age and nighttime ultrafiltration volume of the rapid transit group were higher than those of the non-rapid transit group,while the level of albumin was lower than that of the non-rapid transit group(P＜0.05).The prolonged dialysis age(OR=1.051,95%CI:1.023-1.081)and elevated CTGF(OR= 1.298,95%CI:1.165-1.446),PAI-1(OR=1.408,95%CI:1.205-1.646)were the independent risk factors of rapid transport of PSTR in patients with PD(P＜0.05).The area under the curve of CTGF combined with PAI-1 in dialyzate to predict the rapid transport of PSTR in PD patients was higher than that of either alone(P＜0.05).Conclusion Elevated levels of CTGF and PAI-1 in dialyzate are independently associated with rapid transport of PSTR in PD patients,and CTGF combined with PAI-1 is of higher value in the assessment of rapid transport of PSTR in PD patients,and may become an auxiliary assessment index of PSTR rapid transport in PD patients.
关键词
腹膜透析/结缔组织生长因子/纤溶酶原激活物抑制剂-1/腹膜溶质转运速率/快速转运Key words
Peritoneal dialysis/Connective tissue growth factor/Plasminogen activator inhibitor-1/Peritoneal solute transport rate/Rapid transit引用本文复制引用
基金项目
江苏省卫生健康委医学科研立项项目(S2020088)
江苏省连云港市卫生科技项目(202123)
出版年
2024
NETL
NSTL
万方数据