首页|子痫前期患者血浆可溶性内皮细胞蛋白C受体、外周血总循环微粒、凝溶胶蛋白水平及其临床意义

子痫前期患者血浆可溶性内皮细胞蛋白C受体、外周血总循环微粒、凝溶胶蛋白水平及其临床意义

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目的 探讨子痫前期患者血浆可溶性内皮细胞蛋白C受体(sEPCR)、外周血总循环微粒(MPs)、凝溶胶蛋白(GSN)水平及其临床意义.方法 选取江苏省太仓市中医医院 2021年 3月至 2023年 3月建立产前登记并确诊的子痫前期孕妇 103例作为病例组,同期建立产前登记且健康的孕妇 200 名作为对照组.根据病例组患者疾病严重程度将其分为轻度子痫前期组(71 例)、重度子痫前期组(32 例).比较各组收缩压(SBP)、舒张压(DBP)、sEPCR、活化部分凝血酶时间(APTT)、凝血酶时间(TT)、凝血酶原时间(PT)、血小板计数(PLT)、外周血总循环MPs及GSN;sEPCR、外周血总循环MPs、GSN与患者血压水平的相关性采用Pearson相关分析.结果 病例组SBP、DBP高于对照组,PLT、TT、APTT低于对照组(P<0.05).病例组的sEPCR、外周血总循环MPs高于对照组,GSN低于对照组(P<0.05).重度子痫前期组SBP、DBP高于轻度子痫前期组,PLT低于轻度子痫前期组(P<0.05);两组TT、APTT比较,差异无统计学意义(P>0.05).重度子痫前期组sEPCR、外周血总循环MPs高于轻度子痫前期组,GSN低于轻度子痫前期组(P<0.05).子痫前期患者sEPCR、外周血总循环MPs与SBP、DBP呈正相关(r>0,P<0.05),GSN与SBP、DBP呈负相关(r<0,P<0.05).结论 子痫前期患者sEPCR、外周血总循环MPs升高,GSN降低,并且与病情严重程度有关,可能与子痫前期患者呈高凝状态有一定的关系.
Levels of plasma soluble endothelial cell protein C receptor,total circu-lating microparticles in peripheral blood,and gelsolin in patients with preeclampsia and their clinical significance
Objective To investigate the levels of plasma soluble endothelial cell protein C receptor(sEPCR),total circulating microparticles(MPs)in peripheral blood,and gelsolin(GSN)in patients with preeclampsia and their clinical signi-ficance.Methods A total of 103 pregnant women with preeclampsia who had established prenatal registration and were diagnosed in Taicang Traditional Chinese Medicine Hospital of Jiangsu Province from March 2021 to March 2023 were selected as case group,and 200 healthy pregnant women who had established prenatal registration during the same period were selected as control group.The patients in case group were divided into mild preeclampsia group(71 cases)and severe preeclampsia group(32 cases)according to the severity of the disease.The systolic blood pressure(SBP),diastolic blood pressure(DBP),sEPCR,activated partial thromboplastin time(APTT),thrombin time(TT),prothrombin time(PT),platelet count(PLT),total circulating MPs in peripheral blood,and GSN were compared among each group;correlation of sEPCR,total circulating MPs in peripheral blood,and GSN and blood pressure was performed by Pearson correlation analysis.Results SBP and DBP of case group were higher than those of control group,PLT,TT,and APTT were lower than those of control group(P<0.05).The sEPCR and total circulating MPs in peripheral blood of case group were higher than those of control group,GSN in case group was lower than that in control group(P<0.05).SBP and DBP of severe preeclampsia group were higher than those in mild preeclampsia group,PLT was lower than that of mild preeclampsia group(P<0.05);and there were no significant differences in TT and APTT between two groups(P>0.05).The sEPCR and total circulating MPs in peripheral blood of severe preeclampsia group were higher than those of mild preeclampsia group group,GSN was lower than that of mild preeclampsia group(P<0.05).The sEPCR and total circulating MPs in peripheral blood were positively correlated with SBP and DBP in patients with preeclampsia(r>0,P<0.05),while GSN was negatively correlated with SBP and DBP(r<0,P<0.05).Conclusion In preeclampsia patients,sEPCR and total circulating MPs in peripheral blood are increased,and GSN is decreased,which are related to the severity of the disease,and may be related to the hypercoagulability of preeclampsia patients.

PreeclampsiaGelsolinSoluble endothelial cell protein C receptorTotal circulating microparticles

王敏芳、吴叶丹

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江苏省太仓市中医医院妇产科,江苏太仓 215400

子痫前期 凝溶胶蛋白 可溶性内皮细胞蛋白C受体 总循环微粒

江苏省自然科学基金

BK20210496

2024

中国医药导报
中国医学科学院

中国医药导报

CSTPCD
影响因子:1.759
ISSN:1673-7210
年,卷(期):2024.21(9)
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