Correlation between sex hormone levels and severity of disease and analy-sis of its prognostic factors in perimenopausal period patients with sudden deafness
Objective To investigate the correlation between sex hormone levels and severity of disease and the influencing factors of prognosis in perimenopausal period patients with sudden deafness.Methods A total of 180 perimenopausal period patients with sudden deafness admitted to the Suzhou Ninth People's Hospital,Jiangsu Province from February 2021 to February 2023 were selected and divided into mild group(59 cases),moderate group(82 cases),and severe group(39 cases)according to the degree of hearing impairment.In addition,they were divided into good prognosis group(125 cases)and poor prognosis group(55 cases)after treatment.The levels of sex hormones(luteinizing hormone[LH],estradiol[E 2],progesterone[P],testosterone[T])in patients with different disease degrees were compared,and the correlation between sex hormone levels and disease degrees was analyzed.The clinical data of patients with different prognosis were compared,and the factors influencing the prognosis of perimenopausal period patients with sudden deafness were analyzed by logistic regression model.Results The levels of serum E2 and P in moderate and severe groups were lower than those in mild group,and those in severe group were lower than those in moderate group(P＜0.05).The levels of serum E2and P were negatively correlated with the severity of perimenopausal sudden deafness(rs＜0,P＜0.05).The proportion of patients with tinnitus or vertigo,the proportion of severely impaired hearing,and the serum homocysteine(Hcy)level in the poor prognosis group were higher than those in the good prognosis group,and the serum E 2 and P levels were lower than those in the good prognosis group(P＜0.05).Multivariate analysis showed that there were tinnitus or vertigo(OR=1.765,95%CI:1.254-2.484),severe hearing impairment(OR=1.982,95%CI:1.386-2.834),E2(OR=0.962,95%CI:0.932-0.963),P(OR=0.873,95%CI:0.774-0.985),Hcy(OR=1.595,95%CI:1.174-2.167)were the independent prognostic factors of perimenopausal period patients with sudden deafness(P＜0.05).Conclusion Serum E2 and P levels are significantly different in perimenopausal period patients with different degrees of sudden deafness,and are significantly negatively correlated with the degree of disease,and affected the prognosis of patients.
Perimenopausal period womenSudden deafnessSex hormoneRelevancePrognosis
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