三阴性乳腺癌患者化疗致肝损伤的影响因素分析
Analysis of influencing factors of liver injury induced by chemotherapy in patients with triple-negative breast cancer
徐丹娟 1徐浩 1陈竹1
作者信息
- 1. 江苏省如皋市人民医院化疗科,江苏如皋 226500
- 折叠
摘要
目的 观察三阴性乳腺癌(TNBC)患者化疗致肝损伤的影响因素.方法 选取 2019 年 1 月至 2022 年 9 月江苏省如皋市人民医院收治 92 例TNBC化疗患者,根据化疗期间是否发生药物性肝损伤将其分为病例组(发生肝损伤,70 例)和对照组(无肝损伤,22 例),分析TNBC化疗患者肝损伤相关影响因素.结果 两组化疗方案、合并高血压、肿瘤分期情况、糖尿病史、化疗前白蛋白水平、甘油三酯水平比较,差异有统计学意义(P＜0.05).经logistic回归模型分析,化疗方案(OR=3.128,95%CI:1.397～7.008)、糖尿病史(OR=8.703,95%CI:1.310～57.828)、化疗前白蛋白水平(OR=3.358,95%CI:1.410～7.995)是TNBC患者化疗发生肝损伤的影响因素(P＜0.05).结论 有糖尿病史、化疗前白蛋白水平偏低及顺铂联合多柔比星、紫杉醇方案的TNBC化疗患者发生药物相关肝损伤的风险较高.
Abstract
Objective To observe the influencing factors of chemotherapy induced liver injury in patients with triple-negative breast cancer(TNBC).Methods Ninety-two patients with TNBC treated in Rugao People's Hospital,Jiangsu Province from January 2019 to September 2022 were selected and divided into case group(with liver injury,70 cases)and control group(without liver injury,22 cases)according to whether drug-induced liver injury occurred during chemotherapy.The related influencing factors of liver injury in TNBC patients with chemotherapy were analyzed.Results There were statistically significant differences in chemotherapy regimen,combined hypertension,tumor stage,diabetes history,pre-chemotherapy albumin level,and triglyceride level between the two groups(P＜0.05).Logistic regression model analysis showed that chemotherapy regimen(OR=3.128,95%CI:1.397-7.008),diabetes history(OR=8.703,95%CI:1.310-57.828),pre-chemotherapy albumin level(OR=3.358,95%CI:1.410-7.995)were the influencing factors of liver injury in TNBC patients after chemotherapy(P＜0.05).Conclusion TNBC patients with a history of diabetes,low pre-chemotherapy albumin levels,and Cisplatin combined with Doxorubicin and Paclitaxel Regimen has a higher risk of drug-related liver injury.
关键词
三阴性乳腺癌/化疗/肝损伤/乳腺癌/影响因素Key words
Triple-negative breast cancer/Chemotherapy/Liver injury/Breast cancer/Influencing factor引用本文复制引用
基金项目
江苏省自然科学基金(BK20181086)
出版年
2024
NETL
NSTL
万方数据