A case of acquired hemophilia A secondary to systemic lupus erythemato-sus and literature review
Systemic lupus erythematosus(SLE)is an autoimmune disease that affects multiple organs and systems.During the active phase,it often affects the blood system,but leads to abnormal coagulation factor function and secondary acquired hemophilia A(AHA),which is relatively rare and easily misdiagnosed or missed.This article reports a young female patient with SLE secondary AHA who presented with headache onset,significant prolongation of activated partial thromboplastin time,significant decrease in coagulation factor Ⅷ activity,and gradual appearance of butterfly shaped erythema on the face.The blood routine showed a decrease in three series,and the final diagnosis was SLE secondary AHA.After treatment with glucocorticoids and immunosuppressants,the condition improved and the activity of coagulation factor Ⅷ returned to normal.The main clinical manifestations of AHA are recent spontaneous acute bleeding,even life-threatening.This article reviews relevant literature and summarizes it in order to enhance the understanding of AHA among immunologists in the department of rheumatism.
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