首页|基于数据挖掘探析汪悦教授治疗原发性干燥综合征的用药规律

基于数据挖掘探析汪悦教授治疗原发性干燥综合征的用药规律

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目的 基于数据挖掘探析汪悦教授治疗原发性干燥综合征的用药规律.方法 从江苏省中医院国医脉案记录系统(V3.2)中获取汪教授2022年4月至2023年4月首诊治疗原发性干燥综合征的处方,再运用SPSS Modeler 18.0和SPSS Statistics 26.0对处方进行中药性味、归经、频次统计,关联规则与聚类分析.结果 共获228张处方.治疗的主要证型以阴虚津亏证和气阴两虚证为主.共用中药208味,总计用药3 795味次,药物四气以微寒、寒、平性为主,五味以甘、苦、辛味为主,归经以肺、胃、肝、心、脾、肾经为主.关联规则分析结果以生地黄、干石斛、麦冬、芦根、金银花、黄芩等为核心.聚类分析可得主方2个、新方2个、特色配伍5类.结论 汪教授治疗原发性干燥综合征常用寒苦、甘平之品,从脏腑多经络论治,并挖掘出相关用药规律和新方.
Analysis of the medication rule of Professor Wang Yue in the treatment of primary Sj?gren syndrome based on data mining
Objective To analyse the medication rule of Professor Wang Yue in the treatment of primary Sjögren syndrome based on data mining.Methods The prescription of Professor Wang's first treatment of primary Sjögren syndrome from April 2022 to April 2023 was obtained from the Chinese medical pulse record system(V3.2)of Jiangsu Province Hospital of Chinese Medicine,and SPSS Modeler 18.0 and SPSS Statistics 26.0 were used to analyze the nature and flavour,channel tropism,frequency statistics of traditional Chinese medicine,association rules,and cluster analysis of the prescription.Results A total of 228 prescriptions were obtained.The main types of the treatment were syndrome of yin deficiency and depletion of fluid and syndrome of deficiency of both qi and yin.There were 208 flavors of traditional Chinese medicine,and a total of 3 795 flavors were used.The four nature of drugs were mainly mild cold,cold,and plain,the five flavours of drugs were mainly sweet,bitter,and pungent,and the main channels were lung,stomach,liver,heart,spleen,and kidney.The analysis results of association rules were took raw Rehmanniae Radix,dry Dendrobii Caulis,Ophiopogonis Radix,Phragmitis Rhizoma,Lonicerae Japonicae Flos,Scutellariae Radix,and so on as the core.The cluster analysis could be divided into two different prescriptions,two new prescriptions,and five types of characteristic compatibility.Conclusion Professor Wang's treatment of primary Sjögren syndrome is often made of cold,bitter and sweet,plain drugs,and treatment from zang fu viscera channels.The relevant medication rules and new prescriptions were found out.

Wang YuePrimary Sjögren syndromePrescrip-tionExperienceData mining

李国栋、朱文、黄筱涵、李昱桥、汪悦

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南京中医药大学第一临床医学院,江苏南京 210000

江苏省中医院风湿免疫科,江苏南京 210000

汪悦 原发性干燥综合征 方药 经验 数据挖掘

国家自然科学基金面上项目江苏省研究生实践创新计划项目

82274454SJCX23_0879

2024

中国医药导报
中国医学科学院

中国医药导报

CSTPCD
影响因子:1.759
ISSN:1673-7210
年,卷(期):2024.21(10)
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