Clinical study on the treatment of Stage 2-3 chronic kidney disease with syndrome of qi deficiency of spleen and kidney by self-prepared prescrip-tion based on the"Chunzheng Hehuan"theory
Objective To explore the clinical effect of self-made prescription based on the theory of"Chunzheng Hehuan"on the treatment of Stage 2-3 chronic kidney disease(CKD)with syndrome of qi deficiency of spleen and kidney.Methods A total of 88 patients with Stage 2-3 CKD admitted to Wujin Hospital of Traditional Chinese Medicine,Jiangsu Province from November 2021 to April 2023 were selected and divided into control group and observation group by random number table method,with 44 cases in each group.The control group was treated with Compound α-Ketoacid Tablets,and the observation group was treated with Compound α-Ketoacid Tablets combined with Hehuan Yangshen Prescription which was the self-made prescription.Both groups were treated with one course of treatment for two months,with a total of two courses.The efficacy and drug safety of the two groups were compared,and the scores of traditional Chinese medicine symptoms,signs,renal tubules and renal function before and after treatment were compared.Results The curative effect of observation group was better than that of control group(P＜0.05).After treatment,the scores of traditional Chinese medicine symptoms and signs in both groups were lower than before treatment,and those of observation group were lower than those of control group(P＜0.05).After treatment,the levels of N-acetyl-β-D-glucosidase,α1-microglobulin,β2-microglobulin,retinol-binding protein,blood urea nitrogen,serum creatinine,blood uric acid,cysteine proteinase inhibitor C,and 24 h urinary protein in both groups were lower than before treatment,the levels of α1-microglobulin,retinol binding protein,blood urea nitrogen,blood creatinine,blood uric acid,cysteine proteinase inhibitor C,and 24 h urinary protein in observation group were lower than those in control group(P＜0.05).There was no adverse reaction between the two groups during treatment,and there were no significant differences in alanine transaminase and total bilirubin between the two groups before and after treatment(P＞0.05).Conclusion Based on the theory of"Chunzheng Hehuan",the self-made prescription Hehuan Yangshen Prescription can be used in the clinical treatment of patients with Stage 2-3 CKD,which can significantly improve the effect,improve the clinical traditional Chinese medicine symptoms of patients,enhance the renal tubular function,promote the recovery of renal function,and the drug is safe and controllable.
Chronic kidney diseaseCompound α-Ketoacid TabletsHehuan Yangshen PrescriptionRenal function
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