Clinical effect of Xiezhuo Huayu Granules combined with Bifidobacterium Tetra vaccine Tablets in the treatment of hyperuricemia
Objective To investigate the clinical effect of Xiezhuo Huayu Granules combined with Bifidobacterium Tetravaccine Tablets in the treatment of hyperuricemia(HUA).Methods A total of 150 patients with HUA diagnosed and treated in Wujin Hospital of Traditional Chinese Medicine,Jiangsu Province from November 2021 to May 2023 were selected as the study objects,and they were divided into the western medicine group,the traditional Chinese medicine group,and the combined group by random number table method,with 50 cases in each group.The western medicine group was treated with Bifidobacterium Tetravaccine Tablets,the traditional Chinese medicine group was treated with Chinese medicine Xiezhuo Huayu Granules,and the combined group was treated with Bifidobacter ium Tetravaccine Tablets and Chinese medicine Xiezhuo Huayu Granules.Patients were treated for a total of six weeks.The efficacy,traditional Chinese medicine signs,serum uric acid(UA)level,liver and kidney function indexes,and drug safety were compared among the three groups.Results The clinical effect of the combined group was better than that of the western medicine group and the traditional Chinese medicine group(P＜0.05).After treatment,the scores of balanced constitution in the combined group and the traditional Chinese medicine group were higher than before treatment,and the scores of phlegm-dampness constitution,moist-heat constitution,and blood-stasis constitution in the combined group and the traditional Chinese medicine group were lower than before treatment(P＜0.05).The scores of balanced constitution in the combined group were higher than those in the western medicine group,and the scores of phlegm-dampness constitution,moist-heat constitution,and blood-stasis constitution in the combined group were lower than those in the western medicine group(P＜0.05).There was no significant difference in traditional Chinese medicine physique scores between the combined group and the traditional Chinese medicine group(P＞0.05).After treatment,the UA level in the three groups was lower than that before treatment,and the combined group was lower than that in the western medicine group and traditional Chinese medicine group(P＜0.05).There was no significant difference in the levels of alanine transaminase,aspartate transaminasee,blood urea nitrogen,and blood creatinine among the three groups before and after treatment(P＞0.05).There were no adverse drug reactions in the three groups during treatment.Conclusion Xiezhuo Huayu Granules combined with Bifidobacterium Tetravaccine Tablets for HUA can effectively reduce UA level,improve traditional Chinese medicine signs,and enhance curative effect,while not affecting the liver and kidney function of patients,and the drug is safe.
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