Research progress on mechanism of kaempferol of Epimedii Folium in prevention and treatment of osteoporosis
Kaempferol is the main active component of Epimedii Folium in Berberaceae.It can regulate the proliferation and differentiation of osteoblast and osteoclast,promote the differentiation of bone marrow mesenchymal stem cells into osteoblast,and thus regulate the balance of bone metabolism.In this review,the literature on kaempferol in the treatment of osteoporosi in recent years was reviewed.It is found that kaempferol regulates nuclear factor-κB,estrogen receptor,bone morphogenetic protein/Smads,Runx2,and other related pathways by inhibiting interleukin,tumor necrosis factor,JUN,and other inflammatory factors.Then it affects the differentiation and maturation of osteoblast,osteoclast,and bone marrow mesenchymal stem cells,and inhibits the process of osteoporosis.This paper provides a new scheme and basis for the treatment of osteoporosis and the study of new drugs.
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