淫羊藿中山柰酚防治骨质疏松症的机制的研究进展
Research progress on mechanism of kaempferol of Epimedii Folium in prevention and treatment of osteoporosis
郝庆飞 1袁普卫 1孟庆豪 1赵怡凡 1刘德玉 2王占魁 2余红超2
作者信息
- 1. 陕西中医药大学研究生院,陕西咸阳 712000
- 2. 陕西中医药大学附属医院骨病科,陕西咸阳 712000
- 折叠
摘要
山柰酚是小檗科植物淫羊藿中主要有效成分,可调控成骨细胞、破骨细胞的增殖分化,促进骨髓间充质干细胞向成骨分化,从而调节骨代谢平衡.本文通过检索近年来有关山柰酚治疗骨质疏松症的文献进行综述,发现山柰酚主要是通过抑制白细胞介素、肿瘤坏死因子、JUN等炎症因子,调控核因子κB、雌激素受体、骨形态生成蛋白/Smads、Runx2等相关通路,继而影响成骨细胞、破骨细胞、骨髓间充质干细胞的分化成熟,抑制骨质疏松症的进程.本文为治疗骨质疏松症和研究新药物提供新的方案和依据.
Abstract
Kaempferol is the main active component of Epimedii Folium in Berberaceae.It can regulate the proliferation and differentiation of osteoblast and osteoclast,promote the differentiation of bone marrow mesenchymal stem cells into osteoblast,and thus regulate the balance of bone metabolism.In this review,the literature on kaempferol in the treatment of osteoporosi in recent years was reviewed.It is found that kaempferol regulates nuclear factor-κB,estrogen receptor,bone morphogenetic protein/Smads,Runx2,and other related pathways by inhibiting interleukin,tumor necrosis factor,JUN,and other inflammatory factors.Then it affects the differentiation and maturation of osteoblast,osteoclast,and bone marrow mesenchymal stem cells,and inhibits the process of osteoporosis.This paper provides a new scheme and basis for the treatment of osteoporosis and the study of new drugs.
关键词
山柰酚/骨质疏松症/成骨细胞/破骨细胞/机制Key words
Kaempferol/Osteoporosis/Osteoblast/Osteoclast/Mechanism引用本文复制引用
基金项目
关中李氏骨伤流派传承工作室项目(陕中医药发[2018]40号)
陕西省重点研发计划项目(2022SF-538)
陕西省咸阳市科学技术局重点研发计划项目(2021ZDYF-SF-0036)
出版年
2024
NETL
NSTL
万方数据