Clinical study of bilateral high-frequency repetitive transcranial magnetic stimulation combined with hyperbaric oxygen therapy on swallowing dis-orders after stroke
Objective To explore the clinical effect of bilateral high-frequency repetitive transcranial magnetic stimulation combined with hyperbaric oxygen therapy on swallowing disorders after stroke.Methods A total of 120 patients with swallowing disorders after stroke treated in Xuzhou Central Hospital of Jiangsu Province from January 2022 to March 2023 were selected,and they were divided into observation group and control group according to random number table method,with 60 cases in each group.The control group was treated with unilateral high-frequency repetitive transcranial magnetic stimulation combined with hyperbaric oxygen therapy,while the observation group was treated bilateral high-frequency repetitive transcranial magnetic stimulation combined with hyperbaric oxygen therapy.Both groups were treated with a course of two weeks and a total of three courses of treatment.The clinical efficacy of the two groups was compared.The swallowing function scores(swallowing function assessment scale[SAA],Kuwada drinking water test[KWST],eating assessment tool-10[EAT-10]),electromyography indicators,brain injury markers(neuron-specific enolase[NSE],S100 calcium-binding protein β[S100 β],neurofilament protein light chain[NF-L])before and after treatment were compared between the two groups.Results The clinical effect of the observation group was better than that of the control group(P＜0.05).After treatment,the scores of SAA,KWST,and EAT-10 in both groups were lower than those before treatment,and those of the observation group were lower than the control group(P＜0.05).After treatment,the amplitude and duration of mylohyoid surface electromyography signal in both groups were lower than those before treatment,and the median frequency was higher than before treatment,and the amplitude and duration of mylohyoid surface electromyography signal in the observation group were lower than the control group,and the median frequency was higher than the control group(P＜0.05).After treatment,NSE,S100 β,and NF-L in both groups were lower than those before treatment,and observation group was lower than control group(P＜0.05).Conclusion The bilateral high-frequency repetitive transcranial magnetic stimulation combined with hyperbaric oxygen therapy has a good effect on swallowing disorders after stroke,improving the degree of swallowing disorders and electromyographic indicators,and reducing the level of brain injury markers.
StrokeSwallowing disordersBilateral high-frequencyRepetitive transcranial magnetic stimulationSwallowing functionSurface electromyography
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