Role and predictive value of urinary neurofilament light chain,high-density lipoprotein,and apolipoprotein A1 in cognitive dysfunction in patients with cerebral infarction
Objective To investigate the role and predictive value of urinary neurofilament light chain(uNfL),high-density lipoprotein(HDL),and apolipoprotein A1(ApoA1)in cognitive dysfunction in patients with cerebral infarction.Methods A total of 89 patients with cerebral infarction admitted to NO.904 Hospital of the Joint Logistic Support Force of the Chinese People's Liberation Army from January 2021 to January 2023 were collected.According to the simple mental state examination scale(MMSE),the patients were divided into the normal cognitive function group(52 cases)and the cognitive dysfunction group(37 cases).The uNfL,peripheral blood HDL,and ApoA 1 were recorded and compared between the two groups,logistic regression model was used to incorporate statistically significant indicators into the analysis of influencing factors,and the predictive value was analyzed by subject working characteristic curve.Results uNfL in cognitive dysfunction group was higher than that in normal cognitive function group,HDL and ApoA 1 were lower than those in normal cognitive function group(P＜0.05).uNfL,HDL,and ApoA1 were independent influencing factors of cognitive dysfunction in patients with ischemic cerebral infarction(P＜0.05).The sensitivity and specificity of uNfL were higher than those of HDL and ApoA1.The area under curve of uNfL was larger than that of HDL and ApoA 1(P＜0.05).Conclusion uNfL,HDL,and ApoA1 can be served as important predictive indicators for cognitive dysfunction in patients with cerebral infarction,especially uNfL,which has important clinical value in early identification and prevention of cognitive dysfunction in patients with cerebral infarction.
Urinary neurofilament light chainPost-stroke cognitive impairmentHigh density lipoproteinApolipoprotein A1
NETL
NSTL
万方数据
