Effect of neutrophil extracellular traps and plasminogen activator in-hibitor-1 on the prognosis of premature infants with acute respiratory distress syndrome
Objective To investigate the effect of neutrophil extracellular traps(NETs)and plasminogen activation inhibitor-1(PAI-1)on the prognosis of premature infants with acute respiratory distress syndrome(ARDS).Methods A total of 125 premature infants with ARDS admitted to Beijing Tongzhou District Maternal and Child Health Hospital from January 2020 to December 2022 were selected as ARDS group,and they were divided into good prognosis group and poor prognosis group according to the prognosis of children.The plasma levels of cell free-DNA(cf-DNA),neutrophil elastase(NE),tumor necrosis factor-α(TNF-α),and PAI-1 between two groups were compared;the correlation between cf-DNA and NE,TNF-α in premature infants with ARDS were analyzed;the influencing factors of poor prognosis in premature infants with ARDS were analyzed;and the predictive value of cf-DNA and PAI-1 in premature infants with ARDS was evaluated by receiver operating characteristic curve.Results A total of 125 premature infants with ARDS,47 had poor prognosis and 78 had good prognosis.The levels of cf-DNA,NE,TNF-α,and PAI-1 in poor prognosis group were higher than those in good prognosis group(P＜0.05).cf-DNA was positively correlated with NE and TNF-α in premature infants with ARDS(r=0.645,0.687,P＜0.05).The increased levels of cf-DNA and PAI-1 were risk factors for poor prognosis in premature infants with ARDS(OR=2.188,2.303,P＜0.05).The area under the curve of cf-DNA and PAI-1 combined prediction of premature infants with ARDS was higher than that predicted by each indicator alone(Z=3.272,2.229,P＜0.05).Conclusion The elevated levels of NETs components cf-DNA and PAI-1 are risk factors for poor prognosis in premature infants with ARDS,and the combined detection of these two components has high predictive efficacy for the prognosis of infants with ARDS.
NETL
NSTL
万方数据
