摘要
目的 分析青少年骨肉瘤患者化疗期间的症状群及与生活质量的相关性.方法 选取2023年1月至6月于首都医科大学附属北京积水潭医院接受化疗的青少年骨肉瘤患者85例,采用安德森症状评估量表(MDASI)评估患者化疗期间症状.采用儿童少年生活质量量表(QLSCA)评估生活质量.通过Spearman相关法分析症状群与生活质量的相关性.评估完成后予以针对性干预,比较干预前后的QLSCA评分.结果 85例青少年骨肉瘤患者在化疗期间平均经历(6.12±2.14)个症状,其中食欲缺乏、恶心、疲乏最常见,共提取出4个症状群(消化道、疼痛、呼吸道与神经系统症状群),且各症状群与QLSCA评分均呈负相关(r=-0.268、-0.387、-0.534、-0.301,P＜0.05).患者干预后QLSCA评分高于干预前(P＜0.05).结论 青少年骨肉瘤患者化疗后容易出现症状群,造成生活质量的下降.通过有效的针对性干预可减轻症状,提高生活质量.
Abstract
Objective To analyze the symptom group and its correlation with quality of life in adolescent patients with osteosarcoma during chemotherapy.Methods A total of 85 adolescent osteosarcoma patients who underwent chemotherapy in Beijing Jishuitan Hospital,Capital Medical University from January to June 2023 were selected.The M.D.Anderson symptom inventory(MDASI)was used to evaluate the symptoms of patients during chemotherapy.The quality of life was assessed by the quality of life scale for children and adolescent(QLSCA).Spearman correlation method was used to analyze the correlation between symptom groups and quality of life.Targeted intervention was performed after the evaluation,and QLSCA scores before and after the intervention were compared.Results A total of 85 adolescent patients with osteosarcoma experienced an average of(6.12±2.14)symptoms during chemotherapy,among which loss of appetite,nausea,and fatigue were the most common and serious symptoms.A total of four symptom groups(digestive tract,pain,respiratory tract,and nervous system symptom groups)were extracted,and all symptom groups were negatively correlated with QLSCA score(r=-0.268,-0.387,-0.534,-0.301,P＜0.05).The patients'QLSCA score after intervention was higher than that before intervention(P＜0.05).Conclusion Adolescent patients with osteosarcoma are prone to cluster of symptoms after chemotherapy,resulting in a decline in quality of life.Through effective targeted intervention,symptoms can be alleviated and quality of life can be improved.
基金项目
北京市医院管理中心青年人才培养"青苗"计划(QML20200403)
NETL
NSTL
万方数据