Symptom cluster analysis and its impact on quality of life in adolescent osteosarcoma patients during chemotherapy
Objective To analyze the symptom group and its correlation with quality of life in adolescent patients with osteosarcoma during chemotherapy.Methods A total of 85 adolescent osteosarcoma patients who underwent chemotherapy in Beijing Jishuitan Hospital,Capital Medical University from January to June 2023 were selected.The M.D.Anderson symptom inventory(MDASI)was used to evaluate the symptoms of patients during chemotherapy.The quality of life was assessed by the quality of life scale for children and adolescent(QLSCA).Spearman correlation method was used to analyze the correlation between symptom groups and quality of life.Targeted intervention was performed after the evaluation,and QLSCA scores before and after the intervention were compared.Results A total of 85 adolescent patients with osteosarcoma experienced an average of(6.12±2.14)symptoms during chemotherapy,among which loss of appetite,nausea,and fatigue were the most common and serious symptoms.A total of four symptom groups(digestive tract,pain,respiratory tract,and nervous system symptom groups)were extracted,and all symptom groups were negatively correlated with QLSCA score(r=-0.268,-0.387,-0.534,-0.301,P＜0.05).The patients'QLSCA score after intervention was higher than that before intervention(P＜0.05).Conclusion Adolescent patients with osteosarcoma are prone to cluster of symptoms after chemotherapy,resulting in a decline in quality of life.Through effective targeted intervention,symptoms can be alleviated and quality of life can be improved.
AdolescentsOsteosarcomaDuring chemotherapySymptom groupQuality of life
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