Meta-analysis of clinical efficacy of Compound Danshen Dropping Pills combined with Calcium Dobesilate in the treatment of diabetic retinopathy
Objective To evaluate the clinical effect of Compound Danshen Dropping Pills combined with Calcium Dobesilate in the treatment of diabetic retinopathy(DR).Methods Randomized controlled trials of Compound Danshen Dropping Pills combined with Calcium Dobesilate in the treatment of DR were searched from CNKI,Wanfang Data,VIP,China Biomedical Literature Service System,PubMed,Embase,Web of Science,and Cochrane Library from inception to July 2023.Results A total of 11 clinical randomized controlled trials were included,with a total of 848 patients,425 in the observation group and 423 in the control group.The results of meta-analysis showed that compared with the control group,grayscale value of visual field(mean difference[MD][95％CI]:-0.92[-0.96,-0.88],P＜0.000 01)and volume of hemangioma(MD[95％CI]:-3.11[-3.33,-2.89],P＜0.000 01),blood spot area(MD[95％CI]:-0.76[-0.85,-0.67],P＜0.000 01),macular thickness(MD[95％CI]:-55.62[-62.59,-48.65],P＜O.OO0 01),vascular endothelial growth factor level(MD[95％CI]:-17.63[-21.6,-13.59],P＜0.000 01),tumor necrosis factor-α level(MD[95％CI]:-13.3[-16.09,-10.68],P＜0.000 01)were lower,and visual acuity(MD[95％CI]:0.13[0.05,0.20],P＜0.000 01)was better.No adverse reactions or events occurred.Sensitivity analysis verifies that the model is stable and the conclusion is reliable.Conclusion According to the current clinical evidence,the combination of Compound Danshen Dropping Pills combined with Calcium Dobesilate can improve the clinical efficacy of DR.
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