Characteristics and correlation analysis of clinical indicators in patients with spleen deficiency syndrome of lean nonalcoholic fatty liver disease
Objective To analyze the characteristics of clinical laboratory indicators in patients with spleen deficiency syndrome of lean nonalcoholic fatty liver disease(NAFLD),and to explore correlation between clinical laboratory indicators and spleen deficiency syndrome of lean NAFLD.Methods A total of 336 patients with lean NAFLD were selected from the Department of Gastroenterology Outpatient and Inpatient of Shanghai Putuo District Central Hospital and Shanghai Baiyu Community Health Service Center from December 2019 to December 2021.According to the spleen deficiency syndrome patient report outcome index scale,the NAFLD patients were divided into spleen deficiency syndrome group(195 cases)and non-spleen deficiency syndrome group(141 cases).Basic information,liver and kidney function,blood lipids,routine blood,and tumor indicators of patients were collected,and common clinical laboratory indicators of these patients were compared and analyzed,and correlation analysis of these indicators was performed using SIMCA 14.1 software.Results The mean corpuscular hemoglobin concentration in spleen deficiency syndrome group was lower than that in non-spleen deficiency syndrome group(P＜0.05).The levels of alkaline phosphatase,alanine transaminase,aspartate transaminase,fasting blood glucose,and triglyceride in the spleen deficiency syndrome group were higher than those in the non-spleen deficiency syndrome group,and the levels of creatinine and uric acid were lower than those in the non-spleen deficiency syndrome group(P＜0.01).There was no significant difference in tumor indexes between the two groups(P＞0.05).After principal component analysis,it was found that the difference between the two groups was not obvious.Both X/Y Overview Plot PCA analysis and Loading Scatter Plot indicated hemoglobin,hematocrit,and average hemoglobin content had the greatest significance in ju-dging spleen deficiency syndrome in patients with lean NAFLD.Conclusion Although erythrocyte system parameters are highly correlated with spleen deficiency syndrome,routine laboratory tests may not accurately diagnose and differentiate patients with spleen deficiency syndrome in type NAFLD.
Lean non alcoholic fatty liver diseaseSpleen deficiency syndromeClinical featuresCorrelation
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