Correlation between serum 25 hydroxyvitamin D level and diabetic foot ulcer in elderly patients with type 2 diabetes mellitus
Objective To investigate the correlation between serum 25 hydroxyvitamin D[25(OH)D]level and diabetic foot ulcer(DFU)in elderly patients with type 2 diabetes mellitus(T2DM).Methods A total of 86 elderly T2DM patients with DFU admitted to the Endocrinology Department of the First Affiliated Hospital of Anhui Medical University from January 2019 to January 2021 were selected as the DFU group,and 60 newly diagnosed elderly T2DM patients who were hospitalized during the same period were selected as the T2DM group,without DFU,diabetic lower extremity arterial disease or diabetic peripheral neuropathy.Serum 25(OH)D level was measured by chemiluminescence method.Multivariate logistic regression analysis was used to investigate the relationship between serum 25(OH)D and DFU of T2DM patients.Results In DFU group,the course of diabetes,fasting blood glucose,glycosylated hemoglobin,triglyceride,C-reactive protein,white blood cell count,and erythrocyte sedimentation rate were higher than those in T2DM group(P＜0.05);however,the average sunshine time,high-density lipoprotein cholesterol,serum albumin,hemoglobin,estimated glomerular filtration rate,percutaneous partial pressure of oxygen,ankle brachial index,and serum 25(OH)D levels in the T2DM group were lower than those in the T2DM group(P＜0.05).Multivariate logistic regression analysis showed that low serum 25(OH)D was an independent protective factor for DFU(OR=0.54,95％CI:0.35-0.83,P=0.022).Conclusion There is a close correlation between serum 25(OH)D levels and the onset of DFU in elderly T2DM patients,and high levels of serum 25(OH)D are independent protective factors for DFU.
ElderlyType 2 diabetes mellitusDiabetic foot ulcerVitamin D25 hydroxyvitamin D
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