Study on the correlation between thyroid antibody titers and islet function in patients with type 2 diabetes mellitus combined with Hashimoto thy-roiditis
Objective To investigate the correlation between thyroid-specific antibody titers and pancreatic islet function in patients with type 2 diabetes mellitus(T2DM)and Hashimoto thyroiditis(HT)combined with normal thyroid function.Methods A total of 92 HT patients with normal thyroid and T2DM who were admitted to the Department of Endocrinology of Anqing Municipal Hospital,Anhui Medical University from January 2021 to May 2023 were selected,and they were divided into low C-peptide group(50 cases)and high C-peptide group(42 cases)according to the C-peptide level.Gender,age,duration of diabetes mellitus,glycosylated hemoglobin(HbA1c),body mass index(BMI),thyroid peroxidase antibody(TPOAb),thyroglobulin antibody(TGAb),25 hydroxyvitamin D[25(OH)D],and other indicators were compared between the two groups.Binary logistic regression model was used to analyze the independent risk factors of pancreatic islet function.Results There were statistically significant differences in TPOAb,TGAb,duration of diabetes mellitus,25(OH)D,HbA 1c,and BMI between two groups(P＜0.05).Binary logistic regression analysis showed that,the TPOAb(OR=1.005,95％CI:1.001-1.009),TGAb(OR=1.007,95％CI:1.000-1.014),duration of diabetes mellitus(OR=1.455,95％CI:1.118-1.895),BMI(OR=0.693,95％CI:0.5 17-0.928),and 25(OH)D(OR=0.848,95％CI:0.726-0.991)were independent factors in patients with T2DM(P＜0.05).Conclusion In T2DM patients combined with HT,the titer levels of TPOAb and TGAb are correlated with the degree of islet function damage,and thyroid autoimmune antibody titers are independent risk factor for islet failure.
Type 2 diabetes mellitusHashimoto thyroiditisThyroid autoimmune antibodiesIslet function
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