摘要
目的 探究2型糖尿病(T2DM)伴甲状腺功能正常的桥本甲状腺炎(HT)患者的甲状腺特异性抗体滴度与胰岛功能的相关性.方法 选择2021年1月至2023年5月于安徽医科大学附属安庆市立医院内分泌科就诊的92例甲状腺功能正常的HT伴T2DM患者,根据C肽水平将其分为低C肽水平组(50例)和高C肽水平组(42例).比较两组性别、年龄、糖尿病病程、糖化血红蛋白(HbA1c)、体重指数(BMI)、甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)、25羟维生素D[25(OH)D]等指标.采用二元logistic回归模型分析胰岛功能的独立危险因素.结果 两组TPOAb、TGAb、糖尿病病程、25(OH)D、HbA1c、BMI比较,差异有统计学意义(P＜0.05).二元logistic 回归分析结果显示,TPO Ab(OR=1.005,95％CI:1.001～1.009)、TGAb(OR=1.007,95％CI:1.000～1.014)、糖尿病病程(OR=1.455,95％CI:1.118～1.895)、BMI(OR=0.693,95％CI:0.517～0.928)、25(OH)D(OR=0.848,95％CI:0.726～0.991)是胰岛功能的影响因素(P＜0.05).结论 在T2DM合并HT患者中,TPOAb、TGAb的滴度水平与胰岛功能损伤有关,甲状腺自身免疫性抗体滴度是胰岛功能衰竭的独立危险因素.
Abstract
Objective To investigate the correlation between thyroid-specific antibody titers and pancreatic islet function in patients with type 2 diabetes mellitus(T2DM)and Hashimoto thyroiditis(HT)combined with normal thyroid function.Methods A total of 92 HT patients with normal thyroid and T2DM who were admitted to the Department of Endocrinology of Anqing Municipal Hospital,Anhui Medical University from January 2021 to May 2023 were selected,and they were divided into low C-peptide group(50 cases)and high C-peptide group(42 cases)according to the C-peptide level.Gender,age,duration of diabetes mellitus,glycosylated hemoglobin(HbA1c),body mass index(BMI),thyroid peroxidase antibody(TPOAb),thyroglobulin antibody(TGAb),25 hydroxyvitamin D[25(OH)D],and other indicators were compared between the two groups.Binary logistic regression model was used to analyze the independent risk factors of pancreatic islet function.Results There were statistically significant differences in TPOAb,TGAb,duration of diabetes mellitus,25(OH)D,HbA 1c,and BMI between two groups(P＜0.05).Binary logistic regression analysis showed that,the TPOAb(OR=1.005,95％CI:1.001-1.009),TGAb(OR=1.007,95％CI:1.000-1.014),duration of diabetes mellitus(OR=1.455,95％CI:1.118-1.895),BMI(OR=0.693,95％CI:0.5 17-0.928),and 25(OH)D(OR=0.848,95％CI:0.726-0.991)were independent factors in patients with T2DM(P＜0.05).Conclusion In T2DM patients combined with HT,the titer levels of TPOAb and TGAb are correlated with the degree of islet function damage,and thyroid autoimmune antibody titers are independent risk factor for islet failure.
基金项目
安徽省高等学校科学研究重点项目(2022AH051141)
NETL
NSTL
万方数据