Effects of serum vitamin A and D levels on disease severity and prognosis of neonatal infection
Objective To investigate the relationship between serum vitamin A and D levels and the severity and prognosis of neonatal infection.Methods From April 2020 to April 2022,82 children with neonatal infection hospitalized in Department of Neonatology,Children's Hospital of Soochow University were collected as observation group;they were divided into extremely critical group(20 cases),critical group(25 cases),and non-critical group(37 cases)according to neonatal critical illness;according to the prognosis,they were divided into death group(11 cases)and survival group(71 cases).A total of 80 hospitalized non-infected neonates with different were selected as control group.Serum vitamin A and D levels were compared between observation group and control group;serum vitamin A and D levels in children with neonatal infection neonates with different disease severity were compared.The correlation between serum vitamin A and D levels and different disease severity of children with neonatal infection disease was analyzed;the factors influencing prognosis of children with neonatal infection was analyzed;and the predictive value of serum vitamin A and D in prognosis of children with neonatal infection was evaluated.Results Serum vitamin A and D levels in observation group were lower than those in control group(P＜0.05).Serum vitamin A and D levels in extremely critical group and critical group were lower than those in non-critical group,and serum vitamin A and D levels in extremely critical group were lower than those in critical group(P＜0.05).Serum vitamin A and D levels were negatively correlated with different disease severity of children with neonatal infection disease(r=-0.458,-0.489,P＜0.01).procalcitonin(PCT)and C-reactive protein(CRP)levels in death group were higher than those in survival group,while vitamin A and D levels were lower than those in survival group(P＜0.05).PCT,CRP,vitamin A,and vitamin D were the influencing factors of prognosis of children with neonatal infection(P＜0.05).The area under the curve of vitamin A and D combined prediction prognosis of children with neonatal infection was higher than that of each prediction alone.Conclusion Serum vitamin A and D levels in neonatal infection are closely related to disease severity and prognosis,and can serve as effective prognostic indicators.
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