Research on the mechanism of complications related to dialysis patients with carnitine deficiency
Carnitine,as an intermediate transporter of free fatty acids in and out of mitochondria,plays a vital role in the β oxidation and energy metabolism of fatty acids in the human body.Carnitine deficiency can be life-threatening by hindering mitochondrial energy metabolism,and the main causes of carnitine deficiency include primary insufficiency and secondary excessive losses,and patients receiving dialysis treatment are the more common people with secondary carnitine deficiency.The possible consequences of carnitine deficiency include:toxic effects of intracellular free fatty acid accumulation,hypotension and cardiac changes during dialysis,secondary metabolic disorders of some key enzymes in mitochondria,and altering the stability of cell membranes,increasing red blood cell deformability and osmotic fragility and aggravating anemia,and hypothermia in patients with insufficient oxygen supply to skeletal muscles,resulting in myopathy,muscle weakness,and muscle cramps during dialysis.This article summarizes the production and metabolic pathways,biological functions,and effects of carnitine deficiency on the body,and expounds the pathway mechanism of carnitine deficiency in dialysis patients with kidney disease complicated by cardiac dysfunction,hemodynamic instability,anemia,muscle spasm,etc.,so as to provide a reference for the treatment of complications related to dialysis patients with carnitine deficiency.
CarnitineDialysis treatmentHypotensionAnaemiaCardiologyMuscle function
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