Senile osteoporosis(SOP)as a metabolic bone disease,is characterized by an imbalance in the number of osteoblasts and osteoclasts.Ferroptosis is a new type of cell death characterized by iron-dependent lipid peroxidation and reactive oxygen species accumulation.In recent years,more and more studies have confirmed that the unique biological characteristics of ferroptosis,such as iron overload and lipid peroxides accumulation participating in and affect the occurrence and development of SOP,which is consistent with the theory of"turbid toxicity causing"in traditional Chinese medicine."Turbid toxicity"blocks qi activity,damages qi,blood,yin,and yang,which lays the foundation for the pathogenesis of SOP as the unity of pathogenic factors and pathological products.This paper discuss the relationship between"turbid toxicity"theory,ferroptosis and SOP,explores and expands the pathogenesis of SOP,and provides new ideas for traditional Chinese medicine prevention and treatment of SOP.
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