Bile acid is endogenous signal molecule that affects glucose and lipid metabolism by activating its receptor such as Takeda G pro-tein-coupled receptor 5(TGR5)and farnesol X receptor(FXR).Bile acid metabolism is biphasic with metabolic diseases such as obesity,type 2 di-abetes,non-alcoholic fatty liver disease,etc.TGR5 can not only promote thermogenesis of brown adipose tissue,inhibit hepatic steatosis,enhance insulin sensitivity,but also suppress appetite through central regulation.FXR can regulate the synthesis and transport of bile acids,affecting the oc-currence and development of non-alcoholic fatty liver disease.This article summarizes the research progress on bile acid metabolism and metabolic diseases at home and abroad,and provides some potential biomarkers that may be used for the diagnosis and efficacy evaluation of metabolic dis-eases,in order to provide new ideas for the prevention,diagnosis and treatment of related diseases.
关键词
胆汁酸代谢/糖尿病/肥胖/非酒精性脂肪性肝病
Key words
Bile acid metabolism/Diabetes mellitus/Obesity/Non-alcoholic fatty liver disease
维普
万方数据