Research progress on relationship and mechanism of action between bile acid metabolism and metabolic diseases
Bile acid is endogenous signal molecule that affects glucose and lipid metabolism by activating its receptor such as Takeda G pro-tein-coupled receptor 5(TGR5)and farnesol X receptor(FXR).Bile acid metabolism is biphasic with metabolic diseases such as obesity,type 2 di-abetes,non-alcoholic fatty liver disease,etc.TGR5 can not only promote thermogenesis of brown adipose tissue,inhibit hepatic steatosis,enhance insulin sensitivity,but also suppress appetite through central regulation.FXR can regulate the synthesis and transport of bile acids,affecting the oc-currence and development of non-alcoholic fatty liver disease.This article summarizes the research progress on bile acid metabolism and metabolic diseases at home and abroad,and provides some potential biomarkers that may be used for the diagnosis and efficacy evaluation of metabolic dis-eases,in order to provide new ideas for the prevention,diagnosis and treatment of related diseases.
Bile acid metabolismDiabetes mellitusObesityNon-alcoholic fatty liver disease
万方数据
维普
