Correlation study between magnetic resonance imaging T2* and quality of life in children with severe β thalassemia
Objective To investigate the correlation between magnetic resonance imaging(MRI)T2*and quality of life in children with severe β tha-lassemia.Methods A total of 52 children diagnosed with β thalassemia in the Affiliated Hospital of Guangdong Medical University from January 2015 to January 2022 were selected for cardiac and liver MRI T2*examination,and the quality of life was assessed using the Chinese version of the pediatric quality of life inventory measurement models 4.0(PedsQL4.0).Children with iron overload were divided into two groups according to the presence or absence of cardiac involvement:the liver group(36 cases)had iron overload in the liver,and the heart-liver group(16 cases)had iron overload in both heart and liver.The quality of life and demographic characteristics of the two groups were compared,and the correlation between heart and liver T2*,MRI T2*and the total score of the scale and the scores of each dimension were statistically analyzed.Results The incidence of cardiac iron overload was lower than that of liver iron overload in 52 children(P＜0.05).There was no correlation between T2*in the heart and liver(P＞0.05).There was no significant difference in demographic characteristics between the two groups(P＞0.05).Pearson correlation analysis showed that cardiac T2*was positively correlated with the total score of PedsQL4.0 and physiological function score(P＜0.05).Spearman correlation analysis showed that liver T2*was not correlated with the total score of PedsQL4.0 and all dimension scores(P＞0.05).Conclusion The incidence of cardiac iron overload is lower than that of liver iron overload,and there is no correlation between the two degrees of iron overload.The degree of cardiac iron overload cannot be judged by liver iron overload.The quality of life of β thalassemia children is correlated with cardiac T2*,but not with liver T2*,suggesting that cardiac iron overload is an important factor affecting quality of life.
Severe β thalassemiaMagnetic resonance imagingIron overloadQuality of life
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