Application of Levosimendan in patients with acute myocardial infarction complicated with heart failure
Objective To analyze the application effect of Levosimendan in patients with acute myocardial infarction(AMI)complicated with heart failure.Methods A total of 106 patients with AMI complicated with heart failure admitted to Daxing District People's Hospital in Beijing from January 2018 to November 2022 were selected as the research subjects.They were divided into two groups by a random number table method,with 53 patients in each group.The control group received standardized treatment,while the observation group received simultaneous treatment with Levosimendan.The serum inflammatory factors(high-sensitivity C-reactive protein[hsCRP],interleukin-6[IL-6],and tumor necrosis factor-α[TNF-α]),hemodynamic levels(cardiac index[CI],global end diastolic volume index[GEDVI],and systemic vascular resistance index[SVRI]),cardiac function indicators(left ventricular ejection fraction[LVEF],stroke volume[SV],and B-type natriuretic peptide[BNP])between two groups before and after treatment were compared,and the clinical efficacy and total incidence of adverse reactions between two groups were compared.Results After treatment,the hs-CRP,IL-6,TNF-α,GEDI,SVRI,and BNP of the two groups were all lower than those before treatment,and those in the observation group were lower than those in the control group(P＜0.05);after treatment,the levels of CI,LVEF,and SV in both groups were higher than those before treatment,and those in the observation group were higher than those in the control group(P＜0.05).The clinical efficacy of the observation group was higher than that of the control group(P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion On the basis of standardized treatment,the combination of Levosimendan can ef-fectively alleviate the inflammatory response,stabilize hemodynamics,improve heart function and clinical efficacy in patients with AMI complicated with heart failure,and there are no significant adverse reactions.
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