目的 系统评价脑心通胶囊对缺血性脑卒中二级预防作用.方法 选取中国生物医学文献数据库、中国知网、万方数据知识服务平台、维普网、PubMed、Cochrane Library、Embase、Web of Science核心合集数据库及ClinicalTrials.gov关于脑心通胶囊对缺血性脑卒中二级预防的随机对照试验(对照组用西医常规治疗,试验组加用脑心通胶囊治疗),检索时间为建库至2023年7月.2名研究人员根据纳入及排除标准独立筛选文献,提取相关数据并进行质量评价,使用RevMan5.3软件进行meta分析.结果 本研究共纳入11篇文献,5 081例患者.meta分析结果显示,试验组脑卒中复发率[RR=0.59,95％CI(0.48,0.73),P＜0.00001]、纤维蛋白原[MD=-0.78,95％CI(-0.92,-0.65),P＜0.000 01]、低密度脂蛋白胆固醇[MD=-0.14,95％CI(-0.23,-0.06),P=0.001]、不良反应发生率[RR=0.57,95％CI(0.40,0.81),P=0.002]均低于对照组.结论 脑心通胶囊联合常规药物治疗对缺血性脑卒中的二级预防有较好效果,且安全性较高,临床值得推广.
Meta-analysis of Naoxintong Capsules for secondary prevention of is-chemic stroke
Objective To systematically evaluate the effect of Naoxintong Capsules on secondary prevention of ischemic stroke.Methods CBM,CNKI,Wanfang Data,VIP,PubMed,the Cochrane Library,Embase,Web of Science core collection database,and ClinicalTrials.gov were selected to search for randomized controlled trials of Naoxintong Capsules for secondary prevention of ischemic stroke(the control group was treated with conventional Western medicine,and experimental group was treated with Naoxintong Capsules),the retrieval period was from the establishment of the database to July 2023.Two researchers independently screened the literature according to the inclusion and exclusion criteria,relevant data was extracted and the quality was evaluated.Meta-analysis was performed using RevMan 5.3 software.Results A total of 11 studies involving 5 081 patients were included in this study.The results of meta-analysis showed that the recurrence rate of stroke[RR=0.59,95％CI(0.48 to 0.73),P＜0.000 01],fibrinogen[MD=-0.78,95％CI(-0.92 to-0.65),P＜0.000 01],low density lipoprotein cholesterin[MD=-0.14,95％CI(-0.23 to-0.06),P=0.001],and the incidence of adverse reactions[RR=0.57,95％CI(0.40 to 0.81),P=0.002]in experimental group was lower than those in control group.Conclusion Naoxintong Capsules combined with conventional drugs has good efficacy and high safety in secondary prevention of ischemic stroke,which is worth promoting clinically.
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