Study on the correlation between serum thyroid hormone level and cancer-related fatigue of deficiency of both qi and blood type
Objective To investigate and analyze the status of cancer-related fatigue(CRF)in tumor patients with deficiency of both qi and blood type,and to explore the correlation between CRF and its different severity and thyroid function in these patients.Methods A total of 142 patients with CRF with deficiency of both qi and blood type who visited 19 sub-centers in China from October 2019 to May 2022 were included,and the fatigue status of the patients was assessed by Piper revised fatigue scale in Chinese.Demographic data such as gender,age,monthly family income,education level,and job nature were recorded.As well as body mass index(BMI),Kanofsky performance score(KPS),cancer type and pathological grade,solid tumor efficacy evaluation results,current tumor stage,traditional Chinese medicine symptoms,total triiodothyronine(TT 3),total thyrox-ine(TT4),free triiodothyronine(FT3),free thyroxine(FT4),and thyroid-stimulating hormone(TSH)levels were recorded.According to fatigue state score,the subjects were divided into mild fatigue group(32 cases),moderate fatigue group(92 cases),and severe fatigue group(18 cases).The dif-ference of baseline data among the three groups was compared,and ordered logistic regression analysis was used to explore the influencing factors of CRF degree of deficiency of both qi and blood type.Results There were no significant differences in gender,age,cancer species,family monthly in-come,education level,tumor efficacy evaluation,BMI,job nature,pathological grade,and current stage among the three groups(P＞0.05).There were significant differences in KPS scores among the three groups(P＜0.05).Among them,KPS score of severe fatigue group was lower than that of mild and moderate fatigue groups,and KPS score of moderate fatigue group was lower than that of mild fatigue group(P＜0.05).There were signifi-cant differences in FT3 and TT3 levels among the three groups(P＜0.05).Among them,FT3 level in severe fatigue group was lower than that in mild fatigue group,TT3 level in severe fatigue group was lower than that in mild and moderate fatigue group,and TT 3 level in moderate fatigue group was lower than that in mild fatigue group(P＜0.05).There were no significant differences in FT4,TT4,and TSH levels among the three groups(P＞0.05).There was no significant difference in the number of traditional Chinese medicine symptoms and pale or yellowish complexion,low qi and lazy speech,dizziness,and spontaneous sweating among the three groups(P＞0.05).There were significant differences in palpitation symptoms among the three groups(P＜0.05),Among them,the proportion of central palpitation in severe fatigue group was higher than that in mild and moderate fa-tigue group(P＜0.05).Ordered logistic regression analysis showed that TT3 level(OR=0.167),FT4 level(OR=0.785),KPS score(OR=0.884),no palpitation symptom(P=0.249),and type of non-small cell lung cancer(OR=3.579)were the influencing factors for fatigue degree of CRF patients with deficiency of both qi and blood type(P＜0.05).Conclusion CRF with deficiency of both qi and blood type is related to the neuroen docrine of hypothalamic-pituitary-thyroid axis.Low serum thyroid hormone level is a risk factor for high fatigue degree in patients with CRF.Clinical work should pay attention to the monitoring of thyroid function in patients with tumor.
Cancer-related fatigueThyroid hormoneDeficiency of both qi and blood syndromeNeuroendocrineInfluencing factorslogistic model
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