Clinical effect of Yigong Powder combined with probiotic on alcoholic cirrhosis with dampness stagnancy due to spleen deficiency type
Objective To investigate the curative effect of Yigong Powder combined with probiotic on alcoholic cirrhosis with dampness stagnancy due to spleen deficiency type.Methods A total of 90 patients with alcoholic cirrhosis with dampness stagnancy due to spleen deficiency type ad-mitted to Department of Infectious Liver Disease,Wenzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese Medical University from September 2020 to June 2022 were selected and they were divided into the Yigong Powder group,the probiotic group,and the combined group ac-cording to random number table method,with 30 cases in each group.The Yigong Powder group was given liver cirrhosis base plus Yigong Powder plus probiotic placebo treatment,the probiotic group was given liver cirrhosis base plus probiotic plus Yigong Powder placebo treatment,and the combined group was given liver cirrhosis base plus Yigong Powder plus probiotic therapy.The three groups were treated for three months.The clin-ical efficacy,traditional Chinese medicine syndrome score,liver function,bile acid,intestinal flora,inflammatory factors,and adverse reactions of the three groups were compared.Results The clinical effect of the combined group was better than that of the probiotic group and the Yigong Pow-der group(P＜0.05).The overall analysis found that:there were significant differences in abdominal distension,loose stool due to insufficient in-take,spiritlessness and weakness,pain for both sides scores,glutamic-pyruvic transaminase(GPT),glutamic oxalacetic aminotransferase(GOT),bile acid levels,liver instantaneous elastic value,Escherichia coli,Enterobacter,Enterococcus,Bifidobacterium content,serum tumor necrosis factor-α(TNF-α),interleukin(IL)-6,IL-8,and IL-10 levels among groups,time point comparison and interaction(P＜0.05).Intra-group com-parison:one and three months after treatment,abdominal distension,loose stool due to insufficient intake,spiritlessness and weakness,and pain for both sides scores,GPT,GOT,bile acid levels,Escherichia coli,Enterobacter,and Enterococcus contents,serum TNF-α,IL-6,and IL-8 levels in three groups were lower than before treatment,and those three months after treatment were lower than those one month after treatment(P＜0.05).One and three months after treatment,the instantaneous elastic value of liver in the combined group and the Yigong Powder group was lower than before treatment,and that three months after treatment were lower than that one month after treatment(P＜0.05).One and three months after treatment,the Bifidobacterium content and IL-10 level in the three groups were higher than those before treatment,and those three months after treatment were higher than those one month after treatment(P＜0.05).Comparison between groups:one and three months after treatment,the abdominal distension,loose stool due to insufficient intake,spiritlessness and weakness,and pain for both sides scores,GPT,GOT,bile acid levels,Escherichia coli,En-terobacter,and Enterococcus contents,and serum TNF-α,IL-6,and IL-8 levels in combined group were lower than those in the probiotic group and the Yigong Powder group(P＜0.05).The instantaneous elastic value of liver in the combined group was lower than that in the probiotic group at one and three months after treatment(P＜0.05).The Bifidobacterium content and IL-10 level in combined group were higher than those in the pro-biotic group and the Yigong Powder group at one and three months after treatment(P＜0.05).There was no significant difference in the incidence of adverse reactions between the combined group,the Yigong Powder group,and the probiotic group(P＞0.05).Conclusion The combination of Yigong Powder and probiotic in the treatment of alcoholic cirrhosis with dampness stagnancy due to spleen deficiency type is more helpful to inhibit inflam-mation,improve intestinal microecology and liver function,and can significantly reduce the degree of cirrhosis.
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