哥纳香属植物抗肿瘤作用机制研究进展
Research progress on antitumor action mechanism of Goniothalamus Genus
张新渐 1张建英 2梁玲 2王洪云 1左爱学3
作者信息
- 1. 保山中医药高等专科学校中药学院,云南保山 678000
- 2. 云南中医药大学基础医学院,云南昆明 650500
- 3. 云南中医药大学中药学院,云南昆明 650500
- 折叠
摘要
哥纳香属植物含特征性抗肿瘤活性强的苯乙烯内酯和乙酰精宁类化合物,其作用于肿瘤细胞线粒体膜或线粒体呼吸系统导致细胞凋亡的独特机制引起了极大关注.近年来,从哥纳香属植物中发现了大量具有细胞毒活性的化合物,但相关机制缺乏系统总结,本文对2007年以来哥纳香属植物抗肿瘤机制作一综述,以期为其药物资源的研究提供参考.
Abstract
Goniothalamus genus contains the characteristic components styryl lactone and acetylarginine analogues,which have strong antitumour activity,and their unique action mechanism on the mitochondrial membrane or mitochondrial respiratory system of tumour cells leading to cell apoptosis has attracted great attention.In recent years,a large number of compounds with cytotoxic activity have been discovered from Goniothala-mus genus,but the related mechanisms lack a systematic summary.In this paper,the antitumor mechanism of Goniothalamus genus since 2007 was reviewed in order to provide reference for the research of its drug resources.
关键词
哥纳香属/抗肿瘤/机制Key words
Goniothalamus/Antitumor/Mechanism引用本文复制引用
基金项目
云南省科技厅科技项目中医联合面上项目(2018FF001-067)
保山中医药高等专科学校百名中青年学术技术带头人培养项目(2020X008)
出版年
2024
NETL
NSTL
万方数据