Clinical study of Jiawei Dihuang Decoction in treating elderly diabetic retinopathy with syndrome of yin deficiency of liver and kidney
Objective To explore the clinical efficacy of Jiawei Dihuang Decoction in the treatment of elderly diabetic retinopathy(DR)with syn-drome of yin deficiency of liver and kidney.Methods A total of 108 elderly DR patients with syndrome of yin deficiency of liver and kidney treated in Hainan Traditional Chinese Medicine Hospital from May 2021 to January 2023 were selected and divided into control group and observation group according to random number table method.The control group(54 cases)received routine hypoglycemic and Calcium Isobenesulfonic Acid Capsules,and the observation group(54 cases)received Jiawei Dihuang Decoction on the basis of the control group,with four weeks as a course of treatment for three consecutive courses.The clinical efficacy was compared between the two groups,traditional Chinese medicine syndrome score,visual acuity,blood glucose index(fasting blood glucose[FBG],2 h postprandial blood glucose[2hPG],glycosylated hemoglobin[HbA 1c]),vascular endothelial growth factor(VEGF),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),oxidative stress index(superoxide dismutase[SOD],malondialdehyde[MDA])were compared between the two groups before and after treatment,the safety of treatment was compared between the two groups.Results The clinical effect of the observation group was better than that of the control group(P<0.05).After treatment,traditional Chi-nese medicine syndrome score,FBG,2hPG,HbA1c,VEGF,TNF-α,IL-6,and MDA levels in both groups were lower than those before treatment,while visual acuity and SOD levels were higher than those before treatment.The traditional Chinese medicine syndrome score,FBG,2hPG,HbA 1c,VEGF,TNF-α,IL-6,and MDA levels in the observation group were lower than those in the control group,and the visual acuity and SOD levels were higher than those in the control group(P<0.05).There were no obvious adverse reactions during treatment in both groups.Conclusion Jiawei Dihuang Decoction is effective in the treatment of elderly DR with syndrome of yin deficiency of liver and kidney,which can significantly improve symptoms,improve visual acuity level,and has high safety.
ElderlyDiabetic retinopathySyndrome of yin deficiency of liver and kidneyJiawei Dihuang DecoctionClinical efficacy