Clinical study of Prednisone Tablets combined with Baishao Zonggan Capsules in the treatment of steroid-dependent subacute thyroiditis syn-drome of hyperactivity of fire due to yin deficiency
Objective To investigate the effect of Prednisone Tablets combined with Baishao Zonggan Capsules in the treatment of Steroid-depen-dent subacute(SDSAT)thyroiditis syndrome of hyperactivity of fire due to yin deficiency.Methods A total of 62 patients with SDSATI syndrome of hyperactivity of fire due to yin deficiency admitted to Huaian Cancer Hospital,Jiangsu Province from October 2019 to July 2023 were selected and they were divided into the hormone group and the combination group by random number table method,with 31 cases in each group.The hormone group was treated with Prednisone Tablets with a reduction of 5 mg per week until the drug was discontinued,and the combined group was treated with Baishao Zonggan Capsules on this basis for eight weeks.Traditional Chinese medicine syndrome score,erythrocyte sedimentation rate(ESR),thyroid function index,inflammation index,clinical efficacy,and total incidence of adverse reactions were observed before and after treatment in the two groups.Results After treatment,the traditional Chinese medicine syndrome scores of the two groups were lower than before treatment,and those of the combined group were lower than those of the hormone group(P＜0.05).After treatment,the levels of ESR,free triiodothyronine,and free thy-roxine in two groups were lower than before treatment,and those in the combined group were lower than those in the hormone group.The level of thyroid stimulating hormone in both groups was higher than before treatment,and that in combination group was higher than that in hormone group(P＜0.05).After treatment,the levels of transforming growth factor-β1 in two groups was higher than before treatment,and that in the combined group was higher than that in the hormone group.The levels of interleukin-17 in both groups was lower than before treatment,and that in the com-bination group was lower than that in the hormone group(P＜0.05).The clinical effect of combination group was better than that of hormone group(P＜0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Pred-nisone Tablets combined with Baishao Zonggan Capsules can improve the inflammation level and laboratory indexes of patients,reduce traditional Chinese medicine syndrome scores,improve clinical efficacy,reduce re-currence,and have less adverse reactions and high safety.
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