Correlation between bone metabolism indexes and cardiovascular and cerebrovascular diseases in elderlv patients with chronic kidnev disease
Objective To analyze the correlation between bone metabolism indexes and cardiovascular and cerebrovascular diseases in patients with chronic kidney disease(CKD),and to provide a new means to reduce the incidence of cardiovascular and cerebrovascular diseases.Methods A total of 160 elderly patients with CKD who were hospitalized in Department of Geriatric,Cangzhou People's Hospital,Hebei Province from October 2022 to April 2023 were collected as the study objects.They were divided into the control group(80 cases without cardiovascular and cerebrovas-cular diseases)and the case group(80 cases with cardiovascular and cerebrovascular diseases)according to whether complicated with cardiovascular and cerebrovascular diseases.The clinical data of the two groups were compared,the correlation between bone metabolism indexes and cardiovas-cular and cerebrovascular diseases was analyzed by Pearson,and the influencing factors of cardiovascular and cerebrovascular diseases in elderly patients with CKD were analyzed by multivariate logistic regression analysis.Results There were no significant differences in age,sex,body mass index,CKD stage,and CKD course between the two groups(P＞0.05).The proportion of patients who had smoked or were drinking alcohol in the case group was higher than that in the control group,the levels of triglyceride(TG),total cholesterol(TC)and low density lipoprotein cholesterol(LDL-C)in the case group were higher than those in the control group(P＜0.05),and the levels of high density lipoprotein cholesterol(HDL-C)in the case group were lower than those in the control group(P＜0.05).Serum levels of 25-hydroxyvitamin D3(25-[OH]D3),β-C-terminal telopep-tide of type Ⅰ collagen(β-CTX),and tartrate-resistant acid phosphatase 5b(TRAP5b)in the case group were higher than those in the control group(P＜0.05).Serum levels of osteocalcin(OCN)and procollagen Ⅰ N-terminal propeptide(P Ⅰ NP)in the case group were significantly lower than those in the control group(P＜0.05).There were no significant differences in serum levels of calcium,phosphorus,and parathyroid hormone be-tween two groups(P＞0.05).OCN and P Ⅰ NP levels were negatively correlated with the risk ofcardiovascular and cerebrovascular diseases,serum 25-(OH)D3,β-CTX,and TRAP5b levels were positively correlated with the risk of cardiovascular and cerebrovascular diseases(P＜0.05).There was no correlation between the level of parathyroid hormone and the incidence of cardiovascular and cerebrovascular diseases(P＞0.05).Multivari-ate logistic regression analysis showed that OCN(OR=0.41,95％CI:0.29-0.82),P Ⅰ NP(OR=0.36,95％CI:0.21-0.72),β-CTX(OR=5.65,95％CI:3.23-6.67),TIRAP5b(OR=2.59,95％CI:2.35-3.22),25-(OH)D3(OR=1.1 6,95％CI:1.09-2.25),TG(OR=1.34,95％CI:1.21-2.57),TC(OR=2.1 3,95％CI:1.9 1-2.95),LDL-C(OR=1.79,95％CI:1.61-2.84),and HDL-C(OR=0.33,95％CI:0.23-0.61)levels were the influencing factors of cardiovascular and cerebrovascular diseases in elderly patients with CKD(P＜0.05).Conclusion Bone metabolism indexes in patients with CKD are closely related to the occurrence of cardiovascular and cerebrovascular dis-eases.Monitoring of bone metabolism indexes is crucial to reduce the risk of cardiovascular and cerebrovascular diseases in patients with CKD.
Chronic kidney diseaseBone metabolic markersCardiovascular and cerebrovascular diseases
万方数据
维普
