Correlation between serum fibroblast growth facture-21 and methylenete-trahydrofolate reductase gene polymorphisms and subclinical hypothy-roidism in pregnancy
Objective To explore the relationship between serum fibroblast growth factor-21(FGF-21)and methylenetetrahydrofolate reductase(MTHFR)gene polymorphisms and subclinical hypothyroidism(SCH)in pregnancy.Methods A total of 106 pregnant SCH patients admitted to Linfen People's Hospital of Shanxi Province from July 2022 to July 2023 were selected as SCH group,and 106 healthy pregnant women who un-derwent pregnancy examination in the hospital during the same period were selected as healthy group.The medical records of the two groups were collected,the related factors of SCH were screened,and the efficacy of serum FGF-21 and MTHFR gene polymorphisms in evaluating the occur-rence of SCH was analyzed.Results Fasting blood glucose,serum thyrotropin(TSH),and FGF-21 in SCH group were higher than those in healthy group(P＜0.05).There was statistical significance in the distribution frequency of CC,CT,and TT genotype between the two groups(P＜0.05).The distribution frequency of T allele in SCH group was higher than that in healthy group(P＜0.05).Multivariate analysis showed that serum FGF-21(OR=3.330,95％CI:1.138-9.743)and MTHFR gene polymorphism(OR=4.104,95％CI:1.403-12.008)were the influencing factors of SCH(P＜0.05).The areas under the receiver operator characteristic curves of subjects with single and combined diagnosis of serum FGF-21 and MTHFR gene polymorphism were 0.738,0.670,and 0.851,respectively.Conclusion Pregnant women with elevated serum FGF-21 level and TT genotype of MTHFR gene have higher risk of SCH,and the combination of these two factors has certain diagnostic value.
万方数据
维普
